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The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

The document concludes that understanding hair follicle biology can lead to better hair loss treatments.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.

The Rotterdam Study aims to understand various diseases in older adults.

Estrogens can improve skin aging but carry risks; more research is needed on safer treatments.

Platelet-rich plasma with a new carrier significantly increases hair thickness without serious side effects.

HairMax LaserComb® effectively promotes hair growth and stops hair loss in males with androgenetic alopecia, with no serious side effects.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Estrogen therapy can reduce skin aging but has cancer risks.

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

Hormone therapy is essential for transgender individuals but requires careful management due to possible metabolic effects.

Aging causes skin stem cells to work less effectively.

Exosomes could potentially enhance tissue repair and regeneration with lower rejection risk and easier production than live cell therapies.

Antibiotics can reduce acne but may lead to resistant bacteria, and understanding the skin's bacteria is important for treatment.

Macrophages help heal nerves by aiding the maturation of Schwann cells and are important for nerve repair.

Fat cells in the skin help start healing and form important repair cells after injury.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

The article concludes that the wool follicle is a valuable model for studying tissue interactions and has potential for genetic improvements in wool production.

Androgens can both stimulate and cause hair loss, and understanding their effects is key to treating hair disorders.

Conditioned media from mesenchymal stem cell cultures could be a more effective alternative for regenerative therapies, but more research is needed.

Mutant mice help researchers understand hair growth and related genetic factors.

The article concludes that better understanding gene regulation related to seasonal changes can offer insights into the mechanisms of seasonal timing in mammals.

Treatment of acromegaly can improve women's reproductive health issues caused by hormonal imbalances or tumors.

Fat-derived stem cells, platelet-rich plasma, and biomaterials show promise for healing chronic skin wounds and improving soft tissue with few side effects.

PCOS affects women's health by increasing the risk of diabetes, heart disease, and reproductive issues.

Some plant-based treatments can help with benign prostatic hyperplasia symptoms, but more research is needed to confirm their safety and effectiveness.

Isotretinoin's effects and side effects, like birth defects and depression, might be due to it causing cell death in various cells.

Androgens are important for normal ovarian function and estrogen production, but may not be the main cause of follicle death.