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Glossary Ifosfamide

chemotherapy drug that interferes with cancer cell DNA

Ifosfamide is a chemotherapy drug used to treat various types of cancer, including lymphomas and sarcomas. It works by interfering with the DNA of cancer cells, preventing them from growing and dividing. However, it can also cause side effects like hair loss (alopecia) and damage to the bladder and kidneys, so it is often administered with protective agents to mitigate these risks.

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research Results of Ifosfamide Combination Chemotherapy in Patients with Advanced Soft Tissue Sarcomas

4 citations , January 1987 in “Beiträge zur Onkologie/Contributions to oncology”

This study reported a 21% partial remission rate in patients with advanced soft tissue sarcomas treated with ifosfamide combination chemotherapy, with no complete remissions observed.

research Protection from ifosfamide-induced alopecia by topical thiols in young rats

3 citations , January 1990 in “Cancer chemotherapy and pharmacology”

Topical thiols may prevent hair loss caused by certain chemotherapy drugs.

research Hypertrichosis lanuginosa acquisita following cytotoxic chemotherapy

4 citations , January 1992 in “Clinical Oncology”

This report describes three cases of hypertrichosis lanuginosa acquisita occurring after cytotoxic chemotherapy for cancer, suggesting a possible relationship which is discussed alongside a review of existing literature.

research Resolution of the plantar hyperkeratosis of pachyonychia congenita during chemotherapy for Ewing sarcoma

2 citations , August 2013 in “British Journal of Dermatology”

This case report observed a dramatic improvement in a 15-year-old girl's pachyonychia congenita symptoms during chemotherapy for Ewing sarcoma, suggesting chemotherapy's potential role in managing hyperkeratotic conditions.

research TICE salvage chemotherapy treats germ-cell tumors effectively

April 2007 in “Nature Clinical Practice Urology”

TICE salvage chemotherapy is effective for treating germ-cell tumors with poor prognosis.

research Cytostatics and immunosuppressive drugs

January 1989 in “Side effects of drugs annual”

This chapter reviews studies on the side effects of cytostatics and immunosuppressive drugs, detailing various toxicities such as cardiovascular, pulmonary, and neurotoxicity, but provides no new clinical results.

research Pathobiology of chemotherapy-induced hair loss

218 citations , January 2013 in “The Lancet Oncology”

This review discusses the pathobiology of chemotherapy-induced alopecia and highlights challenges in managing it, reporting no new clinical results and emphasizing the need for well-designed preclinical models to develop effective treatments.

research Protection against chemotherapy-induced alopecia: targeting ATP-binding cassette transporters in the hair follicle?

24 citations , November 2013 in “Trends in pharmacological sciences”

This article describes a potential novel approach to reduce chemotherapy-induced hair loss by enhancing the expression of specific transporters in hair follicles, but reports no clinical results.

research Self-management is beneficial for men with uncomplicated LUTS

April 2007 in “Nature Clinical Practice Urology”

Teaching men with simple bladder problems self-management skills can improve their symptoms and quality of life.

research Efluvio anágeno. Hallazgos tricoscópicos

January 2020 in “Revista Dermatológica Centro Uraga”

This article describes how recognizing distinct trichoscopic features aids in diagnosing various dermatological conditions and hair loss, but it reports no new clinical findings.

research Use of chemotherapy during human pregnancy

724 citations , April 2004 in “Lancet Oncology”

This review summarizes the use and neonatal outcomes of chemotherapy during pregnancy, noting its potential for safe use in the second and third trimesters, and reports no new clinical results.

research Mucocutaneous reactions to chemotherapy

275 citations , March 1999 in “Journal of The American Academy of Dermatology”

This review elaborates on the skin side effects of chemotherapy and emphasizes identifying and managing both common and life-threatening skin reactions, without presenting new clinical findings.

research Chemotherapy-induced alopecia

103 citations , December 2011 in “Journal of the American Academy of Dermatology”

This review discusses current knowledge and management strategies for chemotherapy-induced alopecia, highlighting the need for better research prioritization and providing patient support materials, but reports no new clinical results.

research Drug Reactions Affecting Hair: Diagnosis

85 citations , April 2007 in “Dermatologic Clinics”

This article reviews drug-induced hair changes, highlighting that while many drugs are occasionally linked to hair loss, this connection has been conclusively established for only a few, and such hair loss is typically reversible.

research Docetaxel, cisplatin and 5-fluorouracil in patients with locally advanced unresectable head and neck cancer: a phase I–II feasibility study

78 citations , March 2004 in “Annals of Oncology”

This study found that the combination of docetaxel, cisplatin, and 5-fluorouracil is active and feasible for treating squamous cell carcinoma of the head and neck, with dose level I recommended for further testing.

research Adverse effects of common medications on male fertility

77 citations , June 2015 in “Nature Reviews Urology”

This article reviews the effects of various medications on male fertility, noting that while commonly used drugs can mostly have reversible impacts, conclusive human evidence remains limited.

research DRUG‐ASSOCIATED ALOPECIA

63 citations , March 1995 in “International Journal of Dermatology”

Some drugs can cause hair loss, and stopping these drugs often leads to hair regrowth.

research Anagen effluvium

61 citations , January 2013 in “Indian Journal of Dermatology, Venereology and Leprology”

This review discusses the causes, clinical presentation, and management of anagen effluvium, emphasizing its psychological impact and the need for empathy and practical support, but reports no new results.

research Zinc as an ambivalent but potent modulator of murine hair growth in vivo- preliminary observations

60 citations , October 2005 in “Experimental Dermatology”

This study found that high-dose oral zinc significantly influences hair growth in mice, showing both inhibition and promotion effects depending on the timing and duration of administration.

research Permanent Chemotherapy-Induced Alopecia in Patients with Breast Cancer: A 3-Year Prospective Cohort Study

59 citations , August 2018 in “The oncologist”

This study found that permanent chemotherapy-induced alopecia was relatively common three years after treatment among breast cancer patients receiving adjuvant chemotherapy, particularly those on taxane-based regimens.

research A Clinical and Biological Guide for Understanding Chemotherapy-Induced Alopecia and Its Prevention

38 citations , September 2017 in “Oncologist”

This source reports that scalp cooling is currently the only safe and FDA-cleared method to potentially reduce chemotherapy-induced hair loss, with about a 50% chance of maintaining sufficient hair to avoid needing a wig.

research Hair problems in women

37 citations , January 1997 in “Clinics in Dermatology”

This study found that women with androgenetic alopecia and alopecia areata had significantly lower serum ferritin levels compared to women without hair loss.

research Pathogenesis and treatment options for chemotherapy‐induced alopecia: a systematic review

34 citations , January 2018 in “International Journal of Dermatology”

This review discusses chemotherapy-induced alopecia, highlighting its pathogenesis, clinical patterns, and current therapeutic approaches, with no new clinical results reported.

research Exclamation marks and other trichoscopic signs of chemotherapy-induced alopecia

33 citations , September 2012 in “Australasian Journal of Dermatology”

This article reviews trichoscopic signs of chemotherapy-induced alopecia, including exclamation marks, but reports no new clinical results.

research Alopecia in Association with Malignancy: A Review

26 citations , August 2018 in “American Journal of Clinical Dermatology”

This review discusses the clinical characteristics of alopecia in cancer patients, highlighting its potential role as an associated finding or diagnostic clue, but reports no new clinical results.

research An Update on Drug-Induced Pigmentation

20 citations , October 2018 in “American Journal of Clinical Dermatology”

This article reviews drug-induced pigmentation and reports no new clinical findings, highlighting difficulty in confirming drug associations due to factors like delayed onset and polypharmacy.

research Tamoxifen-Induced Total Alopecia

19 citations , June 2001 in “Annals of Internal Medicine”

This case report describes total alopecia in a 53-year-old woman after 13 months of tamoxifen treatment for breast cancer, with normal hair distribution maintained elsewhere.