Protection from Ifosfamide-Induced Alopecia by Topical Thiols in Young Rats
January 1990
in “
Cancer chemotherapy and pharmacology
”
Studysummary Topical thiols may prevent hair loss caused by certain chemotherapy drugs.
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Researchers developed an animal model using rat pups to test substances that might prevent alopecia caused by oxazaphosphorines. They found that epicutaneous treatment with sodium thioglycollate effectively prevented ifosfamide-induced hair loss in the treated areas. These findings suggested that topical thiols could potentially prevent oxazaphosphorine-induced alopecia in humans.
