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Understanding the genetics of rare inherited ichthyosis syndromes is key for better treatments and genetic counseling.

Premature graying of hair may suggest health issues and currently lacks effective treatments.

Insulin resistance is significantly linked to a higher risk of depression in women with PCOS.

Hormone imbalances can cause specific skin changes, which may help in early detection of endocrine disorders.

To diagnose Polycystic Ovarian Syndrome, two out of three signs—irregular periods, high male hormone levels, or cysts on the ovaries—are needed.

Hair problems can be caused by genetics or the environment, and treatment should focus on the cause and reducing hair damage.

Finasteride caused long-term sexual and non-sexual side effects in young men with hair loss.

Genetic mutations can cause hair growth disorders by affecting key genes and signaling pathways.

Sex hormones may affect COVID-19 severity, with men often faring worse, and targeting related pathways could offer treatment options.

The document suggests creating a validated score to diagnose Cushing's Syndrome and considers plasma steroid profiling as a simpler diagnostic method.

Male skin gets drier and more alkaline as it ages, which may need different skincare than women's skin.

The French Endocrine Society suggests diagnosing PCOS with two of three signs, recommends lifestyle changes and clomiphene for treatment, and calls for more research on certain treatments and tests.

Blocking the prolactin receptor might help treat various diseases, but more research is needed.

The document concludes that identifying the cause of amenorrhea is crucial for proper treatment.

Finasteride treatment in male rats causes long-lasting effects on depression-like behavior, brain cell growth, inflammation, and gut bacteria composition.

Men's hair loss is caused by hormones and genes, and can be treated with medication and surgery, while graying is due to aging and has no prevention except dyeing.

Lower hair zinc and copper levels found in Turkish males with hair loss; higher BMI linked to less hair zinc.

Bariatric surgery may help severely obese teenagers but has risks and requires careful patient selection and long-term care.

5-alpha-reductase inhibitors may reduce COVID-19 symptoms in bald males.

Cyproterone acetate treatment is safe and causes mild feminization, which increases with added estrogen.

A male with aromatase deficiency improved bone health with estradiol treatment.

Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.

The review suggests younger men taking 1 mg finasteride report more side effects, including sexual, skin, metabolic, and psychological issues.

Zinc can help with some skin problems, but its effectiveness varies depending on the condition.

Existing drug dexamethasone may lower death risk in severe COVID-19 cases; more research needed for other drugs.

Premature ovarian insufficiency (POI) can harm women's sexual health, and they may benefit from hormone therapy and counseling.

Hormone therapy affects hair growth in transgender individuals, with testosterone potentially causing hair loss in trans men and estrogen reducing facial/body hair in trans women; treatment options vary.

Dutasteride safely promotes hair growth and reduces hair loss, with mild side effects.

APS-1 in Italy shows diverse AIRE mutations and various autoimmune issues.

Testosterone therapy may slightly improve sexual function in postmenopausal women, but its long-term safety is unknown.