10 citations
,
April 2013 in “Revista cubana de plantas medicinales” This study found that Sida cordifolia L. from Colombia is rich in saponins, which may contribute to its antioxidant and antifungal properties.
149 citations
,
June 2002 in “Veterinary record/The veterinary record” This study found that trilostane was effective in resolving symptoms such as polyuria and polydipsia in many dogs with pituitary-dependent hyperadrenocorticism, with significant hormone level reductions observed.
16 citations
,
August 1989 in “Human Reproduction” This article discusses the complex pathogenesis of hirsutism and reports no new clinical results; further research is needed for better diagnostic and therapeutic strategies.
12 citations
,
January 2004 in “Reproductive biomedicine online” This review discusses the main features of anti-androgen drugs, combined treatments, and insulin sensitizers in managing hirsutism and reports no new research findings.
112 citations
,
April 2009 in “Cochrane library” This review found some evidence suggesting that spironolactone can effectively reduce hirsutism in women but did not support its use for treating acne vulgaris.
November 2018 in “Endocrine Abstracts” A woman's high testosterone levels were caused by a rare ovarian tumor, not the initially diagnosed condition.
82 citations
,
January 2000 in “Hormone Research in Paediatrics” This study describes the enzymatic processes through which DHEA is converted to active sex steroids in human skin, highlighting an androgenic effect on sebaceous glands and estrogenic effects in the vagina.
June 2026 in “Scientific Reports” This study identified hypericin and berberine as compounds that can support hair growth by enhancing oxytocin receptor expression and acting as an oxytocin receptor agonist, respectively, potentially serving as practical alternatives to oxytocin for treating hair-loss diseases.
1 citations
,
April 2018 in “Journal of Investigative Dermatology” In this study, OEA was found to significantly enhance sebaceous lipogenesis and potentially reduce inflammation in human sebocytes, suggesting it as a promising candidate for treating skin dryness.
7 citations
,
February 2016 in “TANG [HUMANITAS MEDICINE]” This study reports that the homeopathic drugs Lycopodium clavatum and Calcarea carbonica showed significant ameliorative effects on polycystic ovarian syndrome symptoms, with some differences in individual symptom response.
2 citations
,
December 2022 in “The Journal of Dermatology” This study found that patients with hidradenitis suppurativa had significantly higher levels of cell-free DNA in their serum compared to healthy controls, suggesting its potential as a biomarker for the disease.
December 2023 in “Expert Review of Endocrinology & Metabolism” In this study, researchers described hyperandrogenism as a condition resulting from excessive androgen production, which can lead to symptoms like acne, hirsutism, and hair loss, particularly relevant for dermatological evaluation and management in adult females.
20 citations
,
May 1990 in “Cleveland Clinic journal of medicine” This study suggests spironolactone, particularly when combined with an oral contraceptive or dexamethasone, may reduce hair symptoms in women with hirsutism, but it should be avoided during pregnancy and in women with a family history of breast cancer.
October 2023 in “Journal of the Endocrine Society” This case report details a 73-year-old woman with significant hirsutism and hair loss linked to a rare ovarian Leydig cell tumor, which was resolved by bilateral salpingo-oophorectomy, normalizing her testosterone levels and addressing her symptoms.
5 citations
,
August 2022 in “International Journal of Women s Health” Women with hyperandrogenism, especially those with PCOS, are more likely to have psychiatric disorders.
4 citations
,
March 2022 in “Journal of Cosmetic Dermatology” This study found that formulations containing saccharide isomerate significantly improved scalp flaking, sebum secretion, and transepidermal water loss compared to placebo in an adult Chinese population with dandruff.
1 citations
,
July 2021 in “Clinical and Experimental Dermatology” This study suggests that finasteride is a safe and effective alternative therapy for women with hidradenitis suppurativa who have contraindications or intolerance to spironolactone.
19 citations
,
March 2008 in “Nature clinical practice endocrinology & metabolism” A combined drug and laser treatment improved hirsutism in a PCOS patient, also enhancing her heart health and requiring regular liver and kidney checks.
July 2022 in “Journal of Investigative Dermatology” This study developed a method to quantify hormones in skin secretions and found that hormonal composition varies by sex and anatomical site.
9 citations
,
September 2000 in “Obstetrics and gynecology clinics of North America” This article reviews the psychological impact of hirsutism, particularly its prevalence among women, and provides no new clinical findings.
12 citations
,
April 1987 in “PubMed” In this study, low-dose spironolactone effectively reduced hirsutism in women and stopped hair loss in one woman with alopecia areata, without significant side effects over 12 menstrual cycles.
7 citations
,
June 2015 in “The anatomical record” This study in Hexi cashmere goats found that secondary follicle activity increases with time, and Hoxc13 expression varies significantly across different growth stages, suggesting a role in follicle activity.
7 citations
,
August 2021 in “ChemEngineering” This study found that Soluplus and L-ascorbyl 2,6-dipalmitate nanoparticles may improve minoxidil's skin permeability through stable hydrophobic interactions, enhancing its potential for targeted skin application.
7 citations
,
April 1992 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” The authors concluded that plasma levels of 3α-diolG, ADTG, and DHTG in women with hyperandrogenic disorders primarily reflect adrenal androgen contributions rather than peripheral action, suggesting a potential index for treatment effectiveness.
4 citations
,
October 2017 in “Indian drugs” This study isolated and characterized several chemical compounds from the leaves and flowers of Hibiscus rosa-sinensis, using spectral data and chemical reactions for structure elucidation.
January 2023 in “Zenodo (CERN European Organization for Nuclear Research)” This study found that hirsutism is a prevalent cosmetic issue among Iraqi women, with most cases being idiopathic and a significant portion having a familial history.
36 citations
,
October 2009 in “Journal of Investigative Dermatology” This study suggests that in SZ95 sebocytes, a pathway for DHT biosynthesis does not require testosterone as an intermediate, potentially impacting the treatment of androgen-sensitive skin conditions.
56 citations
,
August 2005 in “Journal of Investigative Dermatology Symposium Proceedings” This review discusses the complex interaction between androgens and hair follicle biology, highlighting the need for a better understanding to improve hirsutism treatments, but reports no new results.
1 citations
,
September 2025 in “Plant Science Today” This study reported that an herbal formulation containing aqueous extracts of Hibiscus rosa sinensis and Vitex negundo demonstrated promising antimicrobial, antioxidant, anti-inflammatory, and cytotoxic activities, indicating potential health benefits and applications in managing autoimmune diseases.
75 citations
,
August 2006 in “International Journal of Pharmaceutics” The eucalyptus oil system improved skin delivery of hormones, but safety concerns remain.