215 citations,
November 2006 in “Journal of The American Academy of Dermatology” Dutasteride more effective for hair growth, but has more side effects than finasteride.
76 citations,
December 2006 in “Journal of Dermatological Science” Japanese women typically start experiencing hair loss after 40, with reduced hair density and thickness being the main factors.
70 citations,
January 2009 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” Androgens slow hair growth by altering Wnt signaling in balding cells.
51 citations,
February 2009 in “Journal of dermatological science” Pitx2 helps outer root sheath cells differentiate but can't start hair growth on its own.
47 citations,
July 2005 in “British Journal of Dermatology” Topical vitamin D3 does not prevent hair loss from chemotherapy.
37 citations,
August 2016 in “Clinical, Cosmetic and Investigational Dermatology” The document concludes that better treatments for CCCA are needed and more research is required to understand its causes related to hairstyling and genetics.
21 citations,
October 2011 in “PloS one” Certain molecules in hair change with age and could be used for cosmetic treatments.
18 citations,
January 2017 in “Annals of dermatology/Annals of Dermatology” Certain immune cells contribute to severe hair loss in chronic alopecia areata, with Th17 cells possibly having a bigger impact than cytotoxic T cells.
17 citations,
December 2015 in “International Journal of Cosmetic Science” Visible light can improve skin disorders and hair loss, but more research is needed to understand long-term effects.
16 citations,
April 2015 in “Lasers in Surgery and Medicine” Using a fractional laser can stimulate hair growth, but the intensity and duration of inflammation are crucial. Too much can cause ulcers and scarring. Lower beam energy and fewer treatments are recommended to avoid damage.
12 citations,
February 1997 in “British Journal of Dermatology” The enzyme type 1 5α-reductase is more active in the hair follicle's lower part than in the skin's outer layer.
11 citations,
January 2000 in “Journal of Cutaneous Pathology” Short telomeres contribute to aging and cancer, and while telomerase can delay aging, it may also promote cancer.
5 citations,
February 2011 in “Expert Opinion on Drug Discovery” We need better treatments for hair loss, and while test-tube methods are helpful, they can't fully replace animal tests for evaluating new hair growth treatments.
5 citations,
January 2010 in “The anatomical record” Most dogs have hair whorls on their chest and limbs, with shelter dogs and short-haired dogs having more chest whorls.
5 citations,
March 2001 in “Journal of biomechanics” Growing hairs are easier to pull out than resting hairs due to different anchorage strengths.
4 citations,
August 2010 in “Acta Biologica Hungarica” New steroidal compounds moderately block an enzyme related to testosterone conversion, less effectively than finasteride.
4 citations,
February 2007 in “Journal of the European Academy of Dermatology and Venereology” The study suggests silicon might be important for healthy hair, as less silicon was found in people with hair loss.
3 citations,
April 2016 in “Wound Repair and Regeneration” Researchers successfully transplanted hair follicles in mice, which survived well and helped in wound healing.
1 citations,
April 2017 in “Journal of Investigative Dermatology” D-OCT shows increased blood vessel growth in response to tissue damage in Frontal Fibrosing Alopecia and is useful for diagnosis and monitoring.
1 citations,
January 2015 in “Genetics and Molecular Research” Stopping S100A3 activity slows down hair growth in mice.
April 2017 in “Journal of Investigative Dermatology” PRC1 influences skin stem cell development by both turning genes on and off, affecting hair growth and skin cell types.
April 2017 in “Journal of Investigative Dermatology” Blocking JAK-STAT5 signaling in mice leads to hair growth.
April 2017 in “Journal of Investigative Dermatology” The hair follicle dermal sheath is essential for hair shedding and needs to communicate with the outer root sheath for normal hair growth cycles.
June 2002 in “Seminars in Cutaneous Medicine and Surgery” Hair transplantation has improved to more natural-looking results and is complemented by effective non-surgical treatments, with ongoing research into hair follicle cloning.
January 2001 in “Current problems in dermatology” Hair transplantation has improved to use smaller grafts for a natural look and may include follicle cloning in the future; non-surgical treatments are also effective.
316 citations,
June 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” Microspheres about 1.5 micrometers in size can best penetrate hair follicles, potentially reaching important stem cells.
233 citations,
November 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.
179 citations,
April 2012 in “Nature Communications” Regenerated fully functional hair follicles using stem cells, with potential for hair regrowth therapy.
159 citations,
July 2006 in “Endocrine Reviews” Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.
130 citations,
January 1994 in “Differentiation” Mouse hair follicle cells briefly grow during the early hair growth phase, showing that these cells are important for starting the hair cycle.