March 2025 in “Journal of Clinical Medicine” This study highlighted the potential of iron chelators, deferoxamine and deferiprone, to improve hair density, thickness, and elasticity and reduce hair loss by up to 66.8% over six months in individuals with autoimmune alopecia, suggesting they may offer a promising therapeutic option.
This review highlights the increasing global incidence and broad socio-economic impact of celiac disease, emphasizing the need for improved recognition and management to address its multidimensional implications, including comorbidities and dietary challenges.
10 citations
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July 2018 in “Our Dermatology Online” This research reviewed literature to evaluate the role of micronutrients in hair loss and hair growth, examining normal nutrient levels, their role in the hair follicle cycle, and their use in treatments, with data drawn from 92 peer-reviewed articles and reputable health organizations.
1 citations
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February 2024 in “Preprints.org” This review discusses the pharmacology and potential therapeutic effects of rare ginsenoside compound K on metabolic disorders but presents no new clinical results, highlighting the need for further studies on its bioavailability and toxicity.
This study in mice found that maternal iron deficiency led to hair loss and growth abnormalities in offspring due to increased oxidative stress and disrupted signaling pathways, but postnatal iron supplementation was able to reverse these effects.
November 2020 in “IntechOpen eBooks” This review discusses the role of mineral nutrients in human health, emphasizing the importance of dietary sources and education to prevent mineral deficiencies, and reports no new clinical results.
16 citations
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January 2023 in “Gynecological Endocrinology” In this study, researchers found that unexplained liver damage in PCOS patients may involve iron metabolism and the miR-761-hepcidin/GPX4 axis, suggesting potential therapeutic targets.
9 citations
,
November 2007 in “Blood” This study found that a mutation in the Tmprss6 gene disrupts hepcidin regulation, leading to iron deficiency and alopecia in mice, highlighting TMPRSS6's vital role in iron absorption.
This study found that mutations in the TMPRSS6 gene affect the ability of matriptase-2 to inhibit hepcidin, which may impact the molecular pathogenesis of iron-refractory iron-deficiency anemia.
53 citations
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July 2014 in “American Journal of Physiology-Endocrinology and Metabolism” This study found that testosterone-enanthate increased red blood cell production and altered iron homeostasis in older hypogonadal men without being affected by finasteride, indicating these effects do not require type II 5α-reductase enzyme activity.
7 citations
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January 2017 in “Journal of Clinical Biochemistry and Nutrition” This study found that vitamin D was positively associated with serum ferritin levels in Korean women without metabolic syndrome, but this association was not observed in those with metabolic syndrome.
4 citations
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June 2018 in “PLOS ONE” This study found that ferritin levels were positively associated with insulin resistance in non-diabetic Korean men and postmenopausal women, but not in premenopausal women.
2 citations
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January 2017 in “Endocrinology” This chapter reviews the clinical effects of androgens like testosterone and its metabolites on various body systems and life stages, but reports no new results.
October 2020 in “The American Journal of Gastroenterology” This case report highlights how a thorough history and examination led to the diagnosis of hereditary hemochromatosis in a patient initially suspected to have diverticulosis, improving symptoms with phlebotomy treatment.
October 2014 in “Transfusion Clinique et Biologique” This review discusses symptoms and syndromes associated with iron deficiency, with or without anemia, but reports no new clinical findings; the authors highlight the potential influence of intestinal factors on iron absorption.
6 citations
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August 2023 in “Journal of Investigative Dermatology” This study investigated how keratinocytes in the skin respond to different iron levels and found they play a significant role in regulating iron homeostasis by storing iron, affecting epidermal differentiation, and influencing inflammation-related gene expression in mice.
January 2026 in “Revista Eletrônica Acervo Saúde” This study reported that among individuals with long COVID, hematologic disturbances such as inflammation-related anemia, characterized by high hepcidin levels and restricted iron use, were prevalent, contributing to reduced capacity, fatigue, and slow recovery, especially in men and those with severe acute COVID-19.
17 citations
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April 2023 in “Cell Biology International” This review examines the role of red cell distribution width and its association with iron metabolism and other factors in diagnosing and monitoring various anemic and non-anemic conditions, reporting no new clinical findings.
3 citations
,
April 2020 in “American Journal of Case Reports” This case report describes the first instance of juvenile hemochromatosis type 2A associated with secondary hypothyroidism, linked to a novel mutation in the HJV gene.
52 citations
,
October 2010 in “Antiviral Therapy” This review discusses recent advances in monophosphate prodrug strategies for HCV drug discovery, aiming to enhance oral absorption and stability, and reports no new clinical results.
March 2016 in “International Journal of Infectious Diseases” This study reported that peginterferon alpha-2a showed high early and sustained virologic response rates in Albanian hemodialyzed patients with hepatitis C, despite causing several adverse effects.
January 2011 in “Annals of dermatology/Annals of Dermatology” During treatment with interferon/ribavirin for hepatitis C, this study observed significant and lasting improvement in a patient's psoriasis without additional psoriasis-specific therapies.
1 citations
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April 2025 in “Tropical Journal of Natural Product Research” In this study, researchers using network pharmacology and molecular docking methods found that compounds from Avicennia Marina could inhibit hepatitis C virus infection by targeting key proteins such as AKT1 and TNF-α, showing potential for anti-HCV treatments.
17 citations
,
February 2011 in “Expert Opinion on Drug Safety” This review discusses adverse effects associated with pegylated IFN therapy for chronic hepatitis C and highlights the potential of new antiviral drugs to reduce side effects and improve treatment adherence, but reports no new clinical results.
1 citations
,
December 2004 in “Hepatology” This study found that in lamivudine-resistant hepatitis B patients, tenofovir significantly reduced HBV DNA levels faster and more consistently than adefovir, reaching undetectable levels in all treated patients by 44 weeks.
69 citations
,
February 2021 in “PLoS Computational Biology” This study found that securinine and ajmaline significantly inhibited hepatocellular carcinoma cell viability and induced apoptosis, with securinine showing lower toxicity to normal liver cells.
32 citations
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October 2004 in “Pharmacotherapy” In this study, peginterferon alfa-2b plus ribavirin therapy in hepatitis C patients was associated with serious adverse drug reactions in 20% of cases, highlighting differences from clinical trial findings.
10 citations
,
October 2010 in “Hepatology” This case study suggests that treatment with Pil-Food, intended for hair loss prevention, may have triggered postinfantile giant cell hepatitis with autoimmune characteristics, which showed a rapid and effective response to corticosteroid therapy.
39 citations
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January 2008 in “World Journal of Gastroenterology” This report documents the first known case of acute inflammatory demyelinating polyneuropathy potentially linked to pegylated interferon-alpha 2a in a woman undergoing treatment for chronic hepatitis C.
44 citations
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June 2015 in “British Journal of Pharmacology” This study found that betulinic acid inhibits hepatitis C virus replication by suppressing the NF-κB- and ERK1/2-mediated COX-2 pathway, suggesting its potential as a therapeutic supplement.