Acute Inflammatory Demyelinating Polyneuropathy Associated With Pegylated Interferon Alpha 2a Therapy for Chronic Hepatitis C Virus Infection

    January 2008 in “ World Journal of Gastroenterology ”
    Vijay S. Khiani, Thomas J. Kelly, Adeel Shibli, Donald M. Jensen, Smruti R. Mohanty
    Studysummary This report documents the first known case of acute inflammatory demyelinating polyneuropathy potentially linked to pegylated interferon-alpha 2a in a woman undergoing treatment for chronic hepatitis C.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    The document reported the first case of acute inflammatory demyelinating polyneuropathy (AIDP) associated with pegylated interferon-alpha 2a (Pegasys) in a 65-year-old woman undergoing treatment for chronic hepatitis C virus infection. After 16 weeks of combination therapy with Pegasys and ribavirin, the patient developed neurological symptoms such as tingling, numbness, and weakness in her extremities. Diagnostic tests confirmed AIDP, likely linked to Pegasys use. The patient fully recovered with intravenous immunoglobulin (IVIG) treatment, physical therapy, and neurological rehabilitation. The study emphasized the importance of early recognition and management of this rare side effect by healthcare professionals to prevent long-term neurological damage.
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