Bullous Lesions at Polyethylene Glycol Interferon-Alpha-2a Inoculation Site in a Hepatitis C Virus-Infected Subject

    January 2007 in “ Acta Dermato Venereologica ”
    MA Montesu, V Siddi, Rosanna Satta, C Pirodda, Francesca Cottoni
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    Studysummary In this report, a case of a bullous lesion developed at the injection site in a patient treated with PEG-IFN-α-2a for chronic hepatitis C was described. Our plain-language summary of this paper — not a Tressless recommendation.
    A patient with chronic hepatitis C virus (HCV) infection developed a bullous lesion at the inoculation site after treatment with polyethylene glycol interferon-alpha-2a (PEG-IFN-α-2a). This case added to the known dermatological side effects of PEG-IFN, which included both widespread issues like hair loss, pruritus, and vitiligo, and localized issues such as cutaneous ulcerations and necrosis.
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