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    Did you mean T helper 1 cells?
    Glossary T helper 1 cells

    specialized immune cells that produce cytokines to fight infections

    T helper 1 cells, often abbreviated as Th1 cells, are a subset of T cells that play a crucial role in the immune system by producing cytokines like interferon-gamma (IFN-γ). These cytokines help activate macrophages and are essential for defending against intracellular pathogens such as viruses and certain bacteria. Th1 cells are also involved in the pathogenesis of autoimmune diseases by promoting inflammation.

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    1. T helper 17 cell/regulatory T-cell imbalance in hidradenitis suppurativa/acne inversa: the link to hair follicle dissection, obesity, smoking and autoimmune comorbidities 2018 · 66 citations
    2. Imbalance of T‐helper 17 and regulatory T cells in patients with alopecia areata The Journal of Dermatology · 2015 · 62 citations
    3. 42905 Role of regulatory T and T-helper 17 cells in patients with acute diffuse and total alopecia Journal of the American Academy of Dermatology · 2023
    4. The Role of T‐Helper 17 Cells and Regulatory T Cells in Acute Diffuse and Total Alopecia: The Increased Function of Regulatory T Cells May Explain the Favorable Prognosis The Journal of Dermatology · 2025 · 1 citations
    5. MicroRNA-1246 Inhibits NFATc1 Phosphorylation and Regulates T Helper 17 Cell Activation in the Pathogenesis of Severe Alopecia Areata 2023
    6. Detection of subtypes of T helper cells and their cytokines in peripheral blood of patients with systematic lupus erythematosus and their clinical significances Journal of Jilin University · 2014
    7. The Phenotype of Circulating Follicular-Helper T Cells in Patients with Rheumatoid Arthritis Defines CD200 as a Potential Therapeutic Target Clinical & Developmental Immunology · 2012 · 32 citations
    8. P130 The densities of T cells, Langerhans cells, and natural killer cells in uninvolved skin of patients with acne vulgaris Journal of the European Academy of Dermatology and Venereology · 1997
    9. Role of regulatory T cells in psoriasis pathogenesis and treatment British Journal of Dermatology · 2020 · 273 citations
    10. Frontal fibrosing alopecia shows robust T helper 1 and Janus kinase 3 skewing 2020 · 34 citations
    11. CD4 T cells from mice with alopecia areata express an effector like phenotype and can transfer disease The Journal of Immunology · 2023 · 1 citations
    12. The potential of regulatory T cell-based therapies for alopecia areata Frontiers in Immunology · 2023
    13. T Cells Promote Distinct Transcriptional Programs of Cutaneous Inflammatory Disease in Keratinocytes and Dermal Fibroblasts Journal of Investigative Dermatology · 2025 · 2 citations
    14. 290 Brepocitinib improves cicatricial alopecia and downregulates key T-helper biomarkers Journal of Investigative Dermatology · 2024
    15. Decision letter: Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation-induced tissue damage 2021
    16. 176 Myeloid cell-specific deletion of mTOR suppresses psoriasis-like skin inflammation in C57BL/6 mice Journal of Investigative Dermatology · 2023
    17. Class IIa HDAC4 and HDAC7 cooperatively regulate gene transcription in Th17 cell differentiation Proceedings of the National Academy of Sciences · 2024 · 16 citations
    18. The role of natural killer cells in autoimmune blistering diseases Autoimmunity · 2011 · 24 citations
    19. Sphingolipid metabolism orchestrates the establishment of the adult hair follicle stem cell niche to control skin homeostasis bioRxiv (Cold Spring Harbor Laboratory) · 2024
    20. PD-1+CXCR5−CD4+T cells are correlated with the severity of systemic lupus erythematosus Rheumatology · 2019 · 71 citations
    21. A humanized IL-2 fusion protein enhances T regulatory cells in vivo and restrains disease in a murine model of Alopecia Areata 4760 The Journal of Immunology · 2025
    22. CLINICAL AND LABORATORY EVALUATION OF AIDS TRICHOPATHY International Journal of Dermatology · 1993 · 35 citations
    23. ALOPECIA UNIVERSALIS TREATED WITH ORAL CYCLOSPORINE A AND PREDNISOLONE: IMMUNOLOGIC STUDIES International Journal of Dermatology · 1992 · 26 citations
    24. Local IL-17 orchestrates skin aging bioRxiv (Cold Spring Harbor Laboratory) · 2022 · 1 citations
    25. Identification of Biomarkers in Affected Hair Follicles from Chronic Discoid LupusErythematosus by Weighted Gene Co-Expression Network Analysis Research Square (Research Square) · 2022
    26. Identification of Biomarkers in Affected Hair Follicles from Chronic Discoid Lupus Erythematosus by Weighted Gene Co-Expression Network Analysis Research Square (Research Square) · 2022
    27. Pathogenesis of Alopecia Areata in C3H/HeJ Mice and DEBR Rats 2006
    28. What's new in the pathogeneses and triggering factors of bullous pemphigoid The Journal of Dermatology · 2022 · 46 citations
    29. Targeting lymphoid-derived IL-17 signaling to delay skin aging Nature Aging · 2023 · 59 citations
    30. Lupus comédonien Annales de Dermatologie et de Vénéréologie · 2007 · 7 citations