April 2023 in “Journal of Investigative Dermatology” In this study, trypsin digestion was found to be a faster and more efficient method than the explant technique for extracting bulge-derived keratinocytes from adult scalp biopsies.
13 citations
,
November 2013 in “Journal of Endocrinology/Journal of endocrinology” This study found that the vitamin D receptor, but not its ligand, regulates genes involved in hair cycle progression, suggesting a role in integrating hormone signaling pathways for hair and epidermal functions.
20 citations
,
July 2017 in “Scientific Reports” This study found that a novel missense mutation in the vitamin D receptor caused hereditary 1,25-dihydroxyvitamin D-resistant rickets with alopecia by disrupting protein function, highlighting the importance of DNA binding in hair development.
35 citations
,
April 2014 in “American Journal of Medical Genetics” The study reported a significant genotype–phenotype correlation in prepubescent males with XLHED, particularly in the severity of skin and hair manifestations between those with different EDA mutations.
October 2022 in “Dermatology practical & conceptual” This study found that bipolar disorder is more prevalent in patients with hidradenitis suppurativa than in those with psoriasis or in control groups.
December 2024 in “Clinical and Experimental Dermatology” This study found that patients with central centrifugal cicatricial alopecia preferred shared decision-making with their doctors regarding treatment management.
December 2022 in “Skin Pharmacology and Physiology” This study found that most hair shaft abnormalities can be accurately diagnosed using a handheld dermoscope in a clinical setting.
4 citations
,
January 2025 in “Diagnostics” This article reviews the use of high-frequency ultrasonography to visualize nail units and scalps in dermatology, highlighting its potential benefits for disease assessment and treatment monitoring, but reports no new clinical results.
8 citations
,
April 1997 in “Experimental Dermatology” This study found that hHbl gene expression is localized in the cortical cells of the human hair shaft and is notably high in pilomatricoma cells transitioning to hair shaft keratinocytes.
845 citations
,
February 2001 in “The Journal of Clinical Endocrinology & Metabolism” This study identified the presence of the enzyme 1 alpha-hydroxylase in various extrarenal tissues, suggesting its potential role in modulating vitamin D function in peripheral tissues.
September 2022 in “Dermatologic Therapy” This study found that the U.S. stock market responded heterogeneously to the latest presidential elections, with positive reactions in the Energy, Financials, and Industrials sectors but poorer performance among firms with better environmental scores.
25 citations
,
May 1994 in “Journal of Investigative Dermatology” This study identified a novel gene, hacl-1, that is specifically expressed in the hair follicles of ICR mouse skin and is associated with their active state.
37 citations
,
January 1986 in “Carcinogenesis” This study found that TPA treatment transiently induces high levels of ODC in mouse epidermal cells, particularly around hair follicles, with localization reduced by retinoic acid or cycloheximide pretreatment.
April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” According to this study, human scalp hair follicles containing pluripotent stem cells demonstrated the ability to differentiate into cardiac muscle cells and other cell types, suggesting potential applications in heart and nerve regeneration.
28 citations
,
December 2012 in “The American Journal of Cosmetic Surgery” This study reported that treatments using ADSC-CM improved hair growth in all participants, with the most pronounced results after four sessions within three to four months.
1 citations
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May 2024 in “Communications Biology” This study found that Dab2 conditional knockout mice experienced delayed hair follicle cycles and reduced hair follicle stem cell activity, suggesting Dab2's crucial role in regulating stem cell activation and anti-aging process in hair follicles.
April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that HDAC inhibitors, such as Vorinostat and Entinostat, could be effective in promoting hair regrowth in a mouse model of alopecia areata.
88 citations
,
July 2019 in “International Journal of Molecular Sciences” In this study of patients with Androgenic Alopecia, micro-grafts containing HD-AFSCs resulted in significantly improved hair density and follicle count over 11 months compared to a saline solution, suggesting a potential alternative therapy for hair regrowth.
132 citations
,
April 2021 in “Stem Cell Research & Therapy” This study found that exosome-incorporated human amniotic membrane scaffolds notably enhanced diabetic skin wound healing in mice, suggesting potential applications for ADSC-derived exosomes in clinical settings.
2 citations
,
February 1990 in “PubMed” In this study, 1,25-dihydroxyvitamin D3 inhibited growth and promoted differentiation in normal hair follicle cells but did not affect cells from a patient with vitamin D-dependent rickets type II, assisting in potential rapid diagnosis of the condition.
36 citations
,
January 2019 in “Nature communications” This study found that Ldh activity in hair follicle stem cell-mediated squamous cell carcinoma is not necessary for tumorigenesis, as its modulation did not affect the cancer's development or characteristics.
354 citations
,
August 1991 in “Molecular Endocrinology” This study found that distinct isoenzymes of 3 beta-hydroxysteroid dehydrogenase are expressed in human adrenals and gonads compared to the placenta and skin.
April 2023 in “Journal of Investigative Dermatology” In this study, researchers developed a mouse model of scarring alopecia and observed significant reductions in CD200R expression in affected skin, potentially linking this signaling pathway to immune attacks on hair follicles and suggesting new treatment targets for scarring hair loss.
7 citations
,
July 2008 in “Experimental Dermatology” This study identified molecular elements controlling the expression and stabilization of THH protein in hair follicle cells, revealing key mechanisms that support hair shaft development in mice.
October 2022 in “Hair Transplantation” This article discusses tools for measuring hair density in donor areas to guide hair transplant surgery and reports no new clinical results; the authors emphasize the role of digital imaging in achieving consistent outcomes.
57 citations
,
August 1997 in “Pediatrics International” This abstract discusses two types of hereditary vitamin D metabolism defects, VDDR I and VDDR II, and reports on their distinct characteristics and treatment responses, without presenting new clinical data.
1 citations
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September 2002 in “European Journal of Endocrinology” This case study reports the clinical features of triple H syndrome in a 25-year-old man, including ACTH deficiency, alopecia universalis, and anterograde amnesia, which were improved with hydrocortisone treatment.
April 2020 in “The journal of investigative dermatology/Journal of investigative dermatology” This source reports that a study by Liu et al. analyzed genetic factors influencing adalimumab response in hidradenitis suppurativa, finding a specific genetic variant (SNP rs59532114) associated with an inadequate response to the treatment due to increased abscess and inflammatory nodule counts.
June 2021 in “International journal of research in dermatology” This report describes a child and his father with hereditary hypotrichosis simplex, an uncommon isolated form of hair loss, with no other ectodermal or systemic abnormalities noted.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that in a mouse model of Focal Dermal Hypoplasia, treatment with lithium carbonate improved skin disease symptoms compared to controls, though disease severity varied and posed interpretation challenges.