An Endocrinopathy Characterized by Dysfunction of the Pituitary-Adrenal Axis and Alopecia Universalis: Supporting the Entity of a Triple H Syndrome

September 2002 in “ European Journal of Endocrinology ”

Kenji Ichiki, Tomoatsu Nakamura, Naruhiro Fujita, K. Honda, Toru Hiraga, Shun Ishibashi, San‐e Ishikawa

alopecia universalis ACTH deficiency GH deficiency hypoadrenocorticism hydrocortisone pituitary-adrenal axis hair loss corticosteroid

TLDR Triple H syndrome exists and can vary in symptoms.

The document described a case of a 25-year-old man with triple H syndrome, characterized by ACTH deficiency, alopecia universalis, and anterograde amnesia. The patient experienced systematic hair loss, significant weight loss, and was admitted to the hospital due to unconsciousness. Laboratory tests revealed low plasma glucose and deficiencies in GH and ACTH, along with hypoadrenocorticism. Despite low normal intelligence and minor hippocampal changes, treatment with hydrocortisone normalized glucose levels, restored body weight, and promoted hair growth over 7 months. This case supported the existence of triple H syndrome and suggested variability in its presentation.

View this study on eje.bioscientifica.com →

Discuss this study in the Community →

Research cited in this study

1 / 1 results

research The Etiology and Pathogenesis of Alopecia Areata

17 citations , July 1994 in “Journal of Dermatological Science”

The cause of alopecia areata is likely a mix of genetics, immune system issues, and environmental factors, with more research needed to understand it fully.

Related Research

4 / 4 results

research Alopecia Areata: A Multifactorial Autoimmune Condition

148 citations , December 2018 in “Journal of autoimmunity”

Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.

research Treating Resistant Cases of Alopecia Universalis

May 2018 in “Journal of cosmetology & trichology”

Combining platelet-rich plasma therapy with prostaglandin-F eye drops can significantly regrow hair in alopecia universalis.

research A Review on Hair Loss and Damage

January 2016

The article concludes that understanding the causes of hair loss and using continuous treatments like minoxidil and finasteride can help manage it, despite potential side effects.

research Unusual Loss of Body Hair in Childhood: Trichotillomania or Alopecia

2 citations , April 2008 in “Advances in therapy”

Proper diagnosis and treatment of childhood hair loss require distinguishing between alopecia and trichotillomania.

An Endocrinopathy Characterized by Dysfunction of the Pituitary-Adrenal Axis and Alopecia Universalis: Supporting the Entity of a Triple H Syndrome

Research cited in this study

research The Etiology and Pathogenesis of Alopecia Areata

Related Community Posts Join

community Olumiant alternative for Alopecia Areata?

community The worst part of balding is its harder to maintain a balding head

community Actor Jacob Batalon, 26, has a receding hairline. I thought it was pretty cool to see a younger actor being successful, despite dealing with hair loss. His most well known role is Ned Leeds in the Marvel Cinematic Universe, and he is currently the CEO of Sex.

community Just find a cure already, I am totally done

community The shedding caused by Minoxidil is one of the worst things. 2 months apart each picture

community Dr. Tsuji and Riken to make important announcement on their hair cloning cure on Feb 10th.

Related Research

research Alopecia Areata: A Multifactorial Autoimmune Condition

research Treating Resistant Cases of Alopecia Universalis

research A Review on Hair Loss and Damage

research Unusual Loss of Body Hair in Childhood: Trichotillomania or Alopecia