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research Sex Differences in the Hypothalamic–Pituitary–Adrenal Axis’ Response to Stress: An Important Role for Gonadal Hormones

197 citations , January 2019 in “Neuropsychopharmacology”

Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.

research The Local Hypothalamic–Pituitary–Adrenal Axis in Cultured Human Dermal Papilla Cells

9 citations , June 2020 in “BMC Molecular and Cell Biology”

Stress hormone CRF can cause hair loss by affecting hair growth cells and hormones.

research Qiviut Cortisol Reflects Hypothalamic–Pituitary–Adrenal Axis Activity in Muskoxen (Ovibos Moschatus)

7 citations , May 2021 in “General and comparative endocrinology”

Muskoxen's qiviut cortisol levels indicate their stress hormone activity over the hair growth period.

research Involvement of the Central Hypothalamic-Pituitary-Adrenal Axis in Hair Growth and Melanogenesis Among Different Mouse Strains

6 citations , October 2018 in “PLoS ONE”

Stress can slow hair growth and affect skin color by impacting the body's stress response system.

research Alopecia Areata: Hyperactivity of the Hypothalamic–Pituitary–Adrenal Axis Is a Myth?

5 citations , May 2017 in “Journal of the European Academy of Dermatology and Venereology”

The study found no significant difference in stress hormone levels between people with alopecia areata and healthy individuals, suggesting that the disease is not caused by an overactive stress response system.

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community Mechanism of action of alfatradiol (17 alpha estradiol)

in Research/Science 6 upvotes 1 year ago

The conversation discusses the mechanism of action of alfatradiol (17 alpha estradiol) in treating hair loss. It explores theories that it either inhibits 5 alpha reductase to prevent T->DHT conversion or aromatizes scalp T into 17-alpha-estradiol to save hair.

community Anyone remember Breezula, the promising hairloss drug that was perpetually 3 years away? Well, it's available right now as an acme treatment. Can we just directly apply to the scalp?

in Treatment 42 upvotes 4 years ago

The conversation discusses the availability of Breezula, a drug for hair loss, now being sold as an acne treatment, and whether it can be applied to the scalp. Users express skepticism about new hair loss treatments and suggest waiting for FDA approval.

community Transient and Permanent Effects of Finasteride Use

in Research/Science 156 upvotes 4 years ago

Potential side effects of 5AR inhibitors like finasteride and dutasteride. Users debate risks, benefits, and personal experiences with these hair loss treatments.

community EMA is re-examining Winlevi (clascoterone at lower concentration)

in Treatment 7 upvotes 4 months ago

Clascoterone in Winlevi, a topical AR antagonist, is being re-examined due to concerns about HPA axis suppression in adolescents, but it's unlikely to be banned for adult use in androgenetic alopecia (AGA). The European Medicines Agency recommended refusing Winlevi for acne vulgaris, but this may not affect Breezula's approval for AGA.

community There’s actually a quite good chance that next year, we might see a new treatment get FDA approval for the first time in nearly three decades.

in Research/Science 78 upvotes 9 months ago

Breezula, a potential new hair loss treatment, may receive FDA approval soon, but it is expected to be a weaker alternative to finasteride and minoxidil. Concerns include its twice-daily application and possible side effects like HPA axis suppression.

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