Lesional Skin Histology in Drug-Induced Hypersensitivity Syndrome: A Single Center 10-Year Experience of 37 Patients

This retrospective study analyzed skin histology in 37 patients with drug-induced hypersensitivity syndrome (DIHS) at Niigata University Hospital over a decade. The most common histopathological feature observed was interface dermatitis, present in over 90% of patients, followed by dyskeratosis in 54%, vasculitic changes in 43.2%, and local eosinophilia in 24.3%. The study highlights the variability of histological features in DIHS and suggests that these changes may represent different stages or a spectrum of the condition, although further research is needed to confirm this. The study's limitations include its retrospective design and single-center setting.