217 citations
,
July 2009 in “Experimental and Clinical Endocrinology & Diabetes” This study found that hair cortisol levels were significantly higher in patients with Cushing's Syndrome compared to healthy controls, suggesting hair analysis can provide historical information on cortisol exposure.
140 citations
,
December 1998 in “Journal of Investigative Dermatology” Apoptosis in hair follicles varies by growth phase, with TGF-β possibly starting the catagen phase.
139 citations
,
December 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified a new type II cytokeratin, named K6hf, exclusively expressed in the companion layer of the human hair follicle, distinguishing it from other keratins and suggesting a unique biochemical role.
139 citations
,
July 1991 in “Journal of The American Academy of Dermatology” This article discusses the structure of hair follicles and their significance in evaluating hair disorders, but it does not report any new research findings.
102 citations
,
January 2003 in “Dermatology” This review discusses the potential link between smoking and hair loss and suggests that raising awareness about this association could enhance anti-smoking education efforts.
96 citations
,
September 2017 in “Analytica Chimica Acta” This review discusses the growing use of scalp hair for elemental analysis in various fields and highlights advancements in analysis techniques, including the future potential of laser ablation ICP-MS, but reports no new clinical results.
85 citations
,
February 1989 in “Journal of The American Academy of Dermatology” This case report describes a newly identified condition called loose anagen hair of childhood, characterized by easily pluckable hair in two young boys, with variable duration and no scalp inflammation or scarring.
84 citations
,
February 2013 in “Clinica chimica acta” This review presents evidence that correlations exist between hair mineral imbalances and various diseases, though inconsistencies in results highlight the need for standardized preparation methods.
84 citations
,
April 2002 in “Archives of Dermatology” This study found that a keratin mutation may cause diffuse partial woolly hair associated with loose anagen hair syndrome in some families, but other genetic factors could play a role in different cases.
74 citations
,
March 2006 in “Journal of Chromatography B” This review discusses the use of hair analysis for detecting misuse of drugs in livestock, covering hair biology, drug incorporation, sampling methods, and analytical techniques, but reports no new findings.
71 citations
,
December 1987 in “Journal of animal science/Journal of animal science ... and ASAS reference compendium” This review highlights the challenges of using hair mineral analyses as precise indicators of mineral status due to various influencing factors, suggesting they may be informative when combined with other indicators.
67 citations
,
May 2013 in “Therapeutic drug monitoring” This study explores the complexities of interpreting single drug exposure in hair, emphasizing factors like drug distribution variability and suggests methods to validate single exposure findings in forensic cases.
65 citations
,
May 2006 in “Journal of Structural Biology” This study concluded that the curliness of human hair, regardless of ethnicity, originates from the inhomogeneous internal nanostructure due to differences in the distribution of two types of cortices.
61 citations
,
April 2012 in “British Journal of Dermatology” This study analyzed changes in hair diameter and density with age in Caucasian women, highlighting variations in perception of hair amount over time.
60 citations
,
December 2005 in “Biomedical Papers” This article reviews hair analysis for drug detection and its applications in various fields, but reports no new research findings, emphasizing the need to consider the method's complexities and potential pitfalls.
58 citations
,
October 2001 in “Dermatologic Clinics” This review discusses the categorization of hair loss and increased hair density disorders related to systemic diseases and reports no clinical results, emphasizing the potential diagnostic value of history, physical examination, and histopathologic data.
55 citations
,
October 1992 in “Archives of Dermatology” In this study, researchers observed that loose anagen hair syndrome is an autosomal dominant disorder characterized by abnormal hair follicle structure and premature keratinization, possibly due to signaling and desmosomal component disturbances.
52 citations
,
October 2012 in “Journal of Dermatological Science” This review presents updated tables of mouse mutants with hair growth abnormalities to aid in understanding the molecular mechanisms of human hair disorders, but reports no new clinical results.
52 citations
,
February 1986 in “Journal of Histochemistry & Cytochemistry” This study found that monoclonal antibodies can identify specific immunological characteristics of hair fibrous proteins, with some antibodies reacting only with hair proteins and others showing broader activity with skin and epithelial cells.
51 citations
,
November 2010 in “Dermatologic Surgery” This study measured the lengths and depths of different portions of occipital scalp hair follicles and suggested cutting below 1 mm for hair regeneration procedures to avoid damaging the bulge zone.
50 citations
,
March 2018 in “BMC Genomics” This study expands knowledge of non-coding RNAs in goats and other mammals, enhancing understanding of their roles in hair follicle growth and regression.
47 citations
,
October 2016 in “Molecular and Cellular Endocrinology” This study found that DKK1 and WNT10b are paracrine factors that modulate hair follicle stem cell differentiation inhibition, contributing to androgenetic alopecia by affecting Wnt signaling in androgen-sensitive dermal papilla cells after dihydrotestosterone stimulation.
46 citations
,
October 2009 in “Archives of Dermatology” This study found that loose anagen hair syndrome is a common form of alopecia in young girls, typically presenting with thin, sparse hair and usually confirmed by a hair-pull test.
41 citations
,
June 2024 in “Journal of Cellular and Molecular Medicine” This study reviews how oxidative stress affects hair follicle development and hair growth, discusses antioxidant-based treatments for hair loss, and evaluates natural antioxidant products that promote hair growth, emphasizing the need for further research due to existing limitations.
37 citations
,
February 2014 in “Journal of Dermatology” This study found that topical valproic acid significantly increased hair count in male patients with moderate androgenetic alopecia compared to placebo over 24 weeks.
34 citations
,
January 2016 in “Analytical Chemistry” This study reports that a new DART-HRMS method can effectively analyze intact hair for drug use timelines, with cocaine detection aligning with forensic standards and identifying multiple drugs from high-resolution data.
34 citations
,
March 2009 in “Journal of Investigative Dermatology” Proteomic analysis can identify genetic differences in mouse hair, helping understand hair defects and variations.
31 citations
,
February 2020 in “BioMed Research International” This study found that in the Thai population, hair density varies by scalp location and decreases with age, and that Asians generally have lower hair density compared to Caucasian and African populations.
31 citations
,
January 2016 in “Drugs - Real World Outcomes” This review discusses the potential link between direct oral anticoagulants and hair loss, suggesting DOACs may not be a suitable alternative for patients with alopecia from traditional anticoagulants; however, no clinical results are reported.
29 citations
,
August 2011 in “PubMed” This study describes how shotgun proteomics can identify over 300 proteins in hair shafts, potentially allowing for the diagnosis of diseases through noninvasive human proteome sampling.