January 2003 in “Annals of Dermatology” This case report describes a hair structure abnormality associated with iron deficiency anemia, which improved after iron supplementation ceased hair loss and corrected the hair shaft abnormality.
52 citations
,
October 2012 in “Journal of Dermatological Science” This review presents updated tables of mouse mutants with hair growth abnormalities to aid in understanding the molecular mechanisms of human hair disorders, but reports no new clinical results.
71 citations
,
May 2006 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, researchers found that trichothiodystrophy hair brittleness is linked to abnormalities in sulfur content and structural organization, making it prone to breakage.
126 citations
,
January 1987 in “Journal of The American Academy of Dermatology” This article reviews the classification of hair shaft abnormalities, outlining their diagnostic features, but does not present new research findings.
86 citations
,
December 2001 in “Experimental dermatology” This review classifies mutant mice with hair abnormalities into six categories, providing an annotated table that serves as a reference for understanding the molecular controls of hair growth.
6 citations
,
March 2016 in “PLoS ONE” This study characterized hair from a patient with a ribosomopathy and identified distinct differences, including reduced hair thickness and lipid content, compared to family members.
4 citations
,
November 1999 in “PubMed” This article presents five family cases of monilethrix and reports that neither vitamins nor desquamative ointments are effective treatments, although symptoms may spontaneously regress over time.
December 2022 in “The Turkish Journal of Pediatrics” This study reported that hair microscopy can help diagnose rare pediatric neurological diseases, as specific hair characteristics were linked to conditions like giant axonal neuropathy, Griscelli syndrome, and Menkes disease.
16 citations
,
October 2012 in “British Journal of Dermatology” Chemotherapy can cause significant hair thinning and changes in hair texture, while tamoxifen has a smaller effect.
35 citations
,
April 1998 in “PubMed” This study found that activating the erbB-2 oncogene in transgenic mice led to severe skin abnormalities and fatal defects, indicating erbB-2's significant role in skin and hair follicle development.
8 citations
,
February 2014 in “Stem cells translational medicine” This study found that human mesenchymal stem cells overexpressing JAM-A improved hair follicle structure and hair formation in mice by reducing abnormalities such as curved and zigzagged follicles.
15 citations
,
July 2002 in “Clinical and Experimental Dermatology” This review discusses the role of hair microscopy in diagnosing alopecia, stating that while it excludes diagnoses related to hair breakage, it only confirms nonspecific short anagen in alopecia cases.
4 citations
,
August 1971 in “Pediatric clinics of North America/The Pediatric clinics of North America” Childhood hair and scalp disorders can be managed with treatments like cortisone and corticosteroids.
30 citations
,
January 2013 in “International Journal of Trichology” This study found that in Jordanian children, tinea capitis, alopecia areata, and telogen effluvium were the most common causes of hair loss, with nutritional deficiencies such as iron and zinc deficiency also noted as significant factors.
6 citations
,
August 1993 in “Archives of Dermatology” This article describes the first documented case of acquired uncombable hair syndrome in a 39-year-old woman, contributing to the understanding of this rare condition.
49 citations
,
January 2003 in “American Journal of Clinical Dermatology” This review discusses various pediatric hair loss conditions and treatments, highlighting the importance of a holistic approach and noting that no single treatment is universally effective.
3 citations
,
January 2019 in “Jikken doubutsu ihou/Jikken doubutsu/Experimental animals/Jikken Dobutsu” This study reported that knocking out the HR gene in pigs using CRISPR/Cas9 led to hairless eyelids and abnormalities in the thymus and peripheral blood, suggesting pigs as a model for human HR-related hair disorders.
May 2014 in “JAMA Dermatology” Mother and son diagnosed with a rare genetic hair loss condition with no effective treatment.
6 citations
,
November 1988 in “Journal of the American Academy of Dermatology” The document concludes that hair analysis is not good for assessing nutrition but can detect long-term heavy metal exposure.
12 citations
,
March 1981 in “International Journal of Dermatology” This case study reports that selenium shampoo, bacterial infection with trichomycosis axillaris, and possibly strongyloides larvae may have contributed to acquired hair shaft abnormalities resembling trichorrhexis nodosa in two patients.
44 citations
,
January 2005 in “Dermatology” This article reviews the clinical and diagnostic features of hair shaft disorders, emphasizing the role of structured patient assessments and the avoidance of hair trauma, but reports no new results.
December 2022 in “Skin Pharmacology and Physiology” This study found that most hair shaft abnormalities can be accurately diagnosed using a handheld dermoscope in a clinical setting.
9 citations
,
January 1989 in “Journal of Small Animal Practice” This study reports an abnormal onion-shaped swelling on the hair shafts of some Abyssinian cats, affecting the appearance of their coat, though skin and hair structures appear normal under the microscope.
January 2016 in “Journal of Investigative Dermatology” Some cells may slow melanoma growth, a protein could affect skin pigmentation, a gene-silencing method might treat hair defects, skin bacteria changes likely result from eczema, and a defensin protein could help treat multiple sclerosis.
44 citations
,
August 2008 in “Archives of Dermatology” This abstract provides no results; it is a website notification about cookies and general access to JAMA content.
21 citations
,
January 2005 in “Skinmed” This article reviews the structural similarities and common disorders of hair and nails, highlighting their joint involvement in congenital and acquired conditions, but it reports no new clinical results.
43 citations
,
December 2013 in “Seminars in Cell & Developmental Biology” This mini-review discusses human hair follicle development and summarizes genetic disorders linked to abnormalities in hair follicle morphogenesis, structure, or regeneration, but reports no new experimental results.
January 2025 in “Case Reports in Dermatological Medicine” This report describes an eight-year-old girl with severe hair shaft abnormalities who showed significant improvement after a single session of adipose tissue–derived exosome therapy, highlighting its potential as an innovative treatment option and the need for further studies to confirm its efficacy and safety.
5 citations
,
May 2014 in “Clinical and Experimental Dermatology” This study found that novel compound heterozygous mutations in the desmoplakin gene lead to hair shaft abnormalities and can result in lethal cardiomyopathy.
25 citations
,
December 2008 in “Journal of Dermatological Case Reports” In this study, R-CSLM showed promise in evaluating hair shaft diseases by providing high-quality images of hair structures, although further development is necessary for follicle and perifollicular area analysis.