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The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

The Rotterdam Study updated findings on elderly health, focusing on heart disease, genetics, lifestyle effects, and disease understanding.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

Targeted cancer therapies often cause serious skin problems that need careful management.

Accurate diagnosis and effective oral treatment are key to managing tinea capitis and preventing its spread.

Hormone therapy is essential for transgender individuals but requires careful management due to possible metabolic effects.

Early detection and intensive treatment of diseases caused by Staphylococcus aureus toxins are crucial for reducing severe health effects.

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

Women with epilepsy should be monitored for reproductive issues, which can be caused by epilepsy or its treatments, especially when using valproate.

Platelet-rich plasma may have some benefits in dermatology, but there's not enough evidence to widely recommend its use.

Tissue-resident memory T cells can protect against infections and cancer but may also contribute to autoimmune diseases.

Products should be called 'sperm-safe' only after thorough, well-designed tests.

5α-reductase inhibitors increase the risk of sexual dysfunction, especially in men with enlarged prostate.

DNA variants can predict male pattern baldness, with higher risk scores increasing baldness likelihood.

Drug repositioning is becoming more targeted and efficient with new technologies, offering personalized treatment options and growing interest in the field.

Some people experience severe, long-lasting side effects from fluoroquinolone antibiotics, leading to the recommendation of limited use and increased awareness of these risks.

Syphilis has a wide range of symptoms that can look like other diseases, and if not treated, it can progress to a more serious stage, especially in HIV-positive patients.

Epilepsy and certain epilepsy drugs can lead to reproductive problems in women, but changing medication might improve these issues.

In Brazil in 2018, the most common skin issues were acne, photoaging, and nonmelanoma skin cancer, with treatments often including topical medications and sunscreen.

Early onset baldness in men may indicate a condition similar to PCOS, linked to heart disease, diabetes, and prostate issues.

Most Latino farmworkers in the study had skin diseases, with fungal infections being the most common.

Testosterone therapy seems safe and effective for transgender men with proper care, but more long-term research is needed.

Sonidegib and vismodegib are similarly effective for advanced basal cell carcinoma, but sonidegib might have a slightly better safety profile.

Some treatments like methotrexate with prednisone might help juvenile morphea, but more research is needed to confirm.

The Brazilian Society of Dermatology agrees that oral isotretinoin is effective for acne and other skin conditions, and it's safe when monitored, but more research is needed on dosing and duration.

Stress can worsen skin conditions and affect mental health, so doctors should include stress management in skin treatment.

Managing PCOS is hard because it varies a lot, treatments are limited, and there's a lot of false information online.

The 2018 update to the ED care model added a new severity score and stressed a detailed evaluation of both physical and psychological aspects.

Delayed ejaculation is a complex issue caused by psychological, biological, and lifestyle factors, requiring a holistic treatment approach.

Testosterone replacement therapy should be used for men with low testosterone levels and symptoms of hypogonadism, after careful diagnosis and considering individual needs.