2 citations
,
March 2017 in “Sultan Qaboos University medical journal” This case report describes a six-month-old infant with focal scalp hair heterochromia and no detectable underlying abnormalities, which was still present at a one-year follow-up.
1 citations
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May 2012 in “Clinical and Experimental Dermatology” This article discusses the presence of iron in segmented heterochromia of scalp hair and concludes that it occurs without iron-deficiency anemia, reporting no new clinical results.
January 2024 in “Australasian journal of dermatology (Print)” In this case study, researchers documented a Chinese boy with hair color changing to red and identified MC1R genetic mutations as the cause, rather than zinc deficiency, enhancing our understanding of hair heterochromia due to genetic factors.
16 citations
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November 2003 in “Journal of the American Academy of Dermatology” Iron therapy cured the boy's hair color issue.
8 citations
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May 2003 in “Clinical and Experimental Dermatology” This case report suggests that nonsynchronized segmented heterochromia in black scalp hair in a 14-year-old girl may represent premature greying unrelated to deficiencies in iron, copper, zinc, or protein.
October 2019 in “European Journal of Dermatology” This review discusses the diagnosis and treatment of pityriasis rubra pilaris and reports no new clinical results.
18 citations
,
April 1989 in “Archives of Dermatology” This study found that segmented heterochromic scalp hair associated with iron-deficiency anemia in a teenage girl completely recovered following iron supplementation, suggesting a role for iron in hair pigment production.
4 citations
,
January 2011 in “European journal of dermatology/EJD. European journal of dermatology” This article provides an overview of lipedematous scalp, a rare condition characterized by a thickened scalp without hair loss, and emphasizes the need for further research due to limited case reports.
June 2026 in “Clinical and Experimental Dermatology” In this study, researchers observed a rare presentation of alopecia areata characterized by hair shafts with segmental heterochromia and changes in thickness, indicating a fluctuating low-level inflammatory process with recovery periods in the hair's normal characteristics.
June 2025 in “British Journal of Dermatology” This case study describes an uncommon variant of coudability hair in alopecia areata, where intermittent inflammatory processes result in alternating bands of lighter color and reduced hair shaft calibre.
1 citations
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October 2022 in “Dermatology practical & conceptual” Isolated patchy heterochromia with pili annulati can occur without other health issues.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, researchers found that the loss of SETDB1 in epidermal keratinocytes led to altered chromatin states, increased ERV expression, and activation of immune responses, while inhibiting these effects with certain antiviral drugs reduced skin inflammation and hair loss in a mouse model.
June 2026 in “Skin Appendage Disorders” This study suggests that pili annulati is likely more common than traditionally thought, highlighting the importance of recognizing its characteristic clinical and trichoscopic features for accurate diagnosis.
September 2017 in “Journal of Investigative Dermatology” This study found that dermal papilla cells exhibit stage-dependent variation in histone methylation during the hair follicle cycle and display distinct chromatin marker expression when transitioning to in vitro culture.
7 citations
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May 2022 in “Frontiers in Cell and Developmental Biology” This review discusses the molecular mechanisms driving hair follicle degeneration in skin aging and emphasizes the role of the tissue microenvironment on stem cell function, but reports no new research findings.
2 citations
,
January 2018 in “European journal of pediatric surgery reports” This case report described a girl with a cervical lymphangioma whose hair texture unexpectedly changed due to Horner's syndrome following tumor resection surgery.
December 2021 in “Research Square (Research Square)” This study found that repeatedly collecting hair follicles from individuals with fragile X syndrome is feasible for measuring FMR1 and FMRP levels in both home and office settings.
75 citations
,
January 2009 in “International journal of trichology” This review examines the differential aging of melanocytes in hair follicles and skin, and reports no new findings; the authors suggest further research is needed to understand these processes.
47 citations
,
January 2013 in “International Journal of Cosmetic Science” This review explores genetic and lifestyle factors influencing hair diversity and reports no new findings, calling attention to the potential for future discoveries in genetic and epigenetic research.
47 citations
,
January 2013 in “Indian Journal of Dermatology, Venereology and Leprology” This review examines the pathogenesis of premature hair graying and potential treatment avenues, but reports no new experimental outcomes, highlighting ongoing research challenges and hopes for drug development.
20 citations
,
January 2015 in “Current problems in dermatology” This paper reviews recent research on hair graying, suggesting that an imbalance in oxidative stress handling may affect melanocyte stem cells and melanin production with age, and calls for exploring strategies to prolong melanin production.
2 citations
,
January 2017 in “Journal of Pigmentary Disorders” This study explores the complex and not yet fully understood causes of premature hair greying, noting genetic factors such as Pax3 and MITE genes, potential defects in melanin transfer, and associations with certain syndromes, while stating that effective treatments are currently lacking.
1 citations
,
September 2024 in “Quality in Sport” This review explores the complex biological process of hair graying, highlighting oxidative stress, genetic factors, and interventions like antioxidants and genetic therapy as key aspects affecting the preservation of hair pigmentation.
1 citations
,
January 2013 in “Elsevier eBooks” The document reviews various hair and nail disorders, their causes, and treatments, emphasizing the need for proper diagnosis and the link between nail changes and systemic diseases.
This review discusses the role of nutrients in hair graying management and finds a possible link between low copper, iron, and vitamin B12 levels and premature hair graying.
54 citations
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June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” This speculative review discusses hair cycle-dependent fibroblast dynamics and possible impacts on human hair growth, synthesizing current literature without presenting new clinical findings.
41 citations
,
September 2012 in “Cellular and Molecular Life Sciences” This review summarizes the current understanding of microRNAs in skin biology, highlighting their roles in processes like wound-healing and aging, without presenting any new experimental results.
31 citations
,
April 2016 in “Nature communications” This study found that in adult mouse skin, reduced levels of histone H3 K4/K9/K27me3 during hair follicle stem cell quiescence are linked to proper tissue homeostasis.
26 citations
,
November 2016 in “European Journal of Clinical Pharmacology” This study found that using valproic acid during radiotherapy for glioma was associated with delayed hair loss and improved survival outcomes.
16 citations
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October 2019 in “Biological & Pharmaceutical Bulletin” This study suggests that Houttuynia cordata extract may promote hair growth by stimulating dermal papilla cell proliferation and extending the anagen phase through enhanced energy metabolism and gene expression changes.