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PRP therapy for alopecia shows inconsistent results due to natural variability in growth factor secretion by platelets.

Dupilumab can improve both atopic dermatitis and alopecia universalis.

ILC1-like cells can cause alopecia areata by attacking hair follicles.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

The document concludes that mouse models are helpful but have limitations for skin wound healing research, and suggests using larger animals and genetically modified mice for better human application.

The immune system plays a key role in tissue repair, affecting both healing quality and regenerative ability.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

The guidelines suggest a detailed approach to diagnosing and treating lupus, with a focus on regular check-ups, personalized medicine, and a range of drug options for different cases.

Certain cells from hair follicles can create new hair and contribute to hair growth when implanted in mice.

Scientists have found a way to create hair follicles from skin cells of newborn mice, which can grow and cycle naturally when injected into adult mouse skin.

Understanding hair growth involves complex interactions between molecules and could help treat hair disorders.

Periodontal ligament stem cells show promise for regrowing tissues but require more research for safe, effective use.

Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.

Understanding the mouse hair cycle is crucial for cancer research.

Treating psoriasis on the scalp, nails, and skin folds is challenging, often requiring systemic treatments for severe cases, with some success in topical and biologic treatments.

An imbalanced gut and lack of biotin can cause hair loss in mice.

White lupin uses specific genes to grow root hairs and access phosphorus when it's scarce.

Fat-derived stem cells, platelet-rich plasma, and biomaterials show promise for healing chronic skin wounds and improving soft tissue with few side effects.

Janus kinase inhibitors are promising drugs for treating autoimmune and inflammatory diseases.

The FOXN1 gene is crucial for developing immune cells and preventing immune disorders.

Neurosteroids show promise for treating epilepsy and more research is needed.

Blocking the CXCR3 receptor reduces T cell accumulation in the skin and prevents hair loss in mice.

PRP treatment may stimulate hair growth by promoting blood vessel formation, increasing growth factors, and preventing cell death.

Certain proteins, caspases-1 and -11, are important in the early development of skin inflammation in mice.

The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.

PRP therapy may effectively treat hair loss, but more research needed.

Keratins are important for skin cell health and their problems can cause diseases.

Excessive hair growth in women often has no known cause and is not linked to race or other hormonal symptoms.