94 citations
,
April 2002 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” This study describes the first case of female pseudohermaphroditism due to a novel homozygous glucocorticoid receptor gene mutation, indicating possible pre- and postnatal virilization in affected females.
86 citations
,
June 2017 in “Anais Brasileiros de Dermatologia” This review discusses the role of antioxidants in managing oxidative skin damage and reports no new results, emphasizing the need for understanding their mechanisms, limitations, and risks for safe use.
84 citations
,
October 2014 in “PLoS Genetics” This study found that epidermal Wnt production is crucial for forming the skin's spinous layer through a BMP-FGF signaling cascade, although Wnt from basal cells is not needed for their differentiation.
65 citations
,
May 2010 in “Current Women's Health Reviews” This review discusses oxidative stress's role in polycystic ovary syndrome and examines various biomarkers to understand its impact on the disorder's pathogenesis, but reports no new clinical results.
61 citations
,
May 2010 in “Integrative Cancer Therapies” This review discusses the potential benefits and risks of selenium in cancer prevention and treatment, emphasizing that while selenium may offer advantages for tumor patients, further research is needed due to mixed findings regarding diabetes risk.
47 citations
,
May 1995 in “Journal of Investigative Dermatology” Hair follicles in people with alopecia have lower levels of a key blood vessel growth protein.
44 citations
,
February 2012 in “The journal of neuroscience/The Journal of neuroscience” This study observed that Ptprq mutant mice exhibit significant abnormalities in hair bundle structure and vestibular dysfunction, suggesting similar issues may contribute to hearing loss and vestibular problems in humans with PTPRQ mutations.
42 citations
,
March 2008 in “Molecular and Cellular Endocrinology” This review explores the potential (neuro-)endocrine influences on hair follicle epithelial stem cell biology and emphasizes the need for more systematic research, but it provides no new empirical results.
41 citations
,
November 1987 in “British Journal of Dermatology” This article reports on the use of ketoconazole for treating cutaneous leishmaniasis, but includes no new clinical trial findings.
39 citations
,
October 2014 in “Schweizerische medizinische Wochenschrift” This study found that while cyclophosphamide remains effective for severe autoimmune conditions, it is associated with gastrointestinal side effects, infections, some cases of irreversible amenorrhoea, and a higher risk of malignancies, emphasizing the need for long-term monitoring.
30 citations
,
November 1996 in “Archives of Dermatology” This report describes cases of increased hair loss and scalp sunburns in patients using 3% minoxidil and 0.01% tretinoin, suggesting caution with tretinoin use on sunny days.
30 citations
,
October 2021 in “Scientific Reports” This study found that human scalp hair follicles can internally operate a Cori cycle, synthesize glycogen in the presence of lactate, and modulate growth through glycogen phosphorylase activity.
27 citations
,
July 1994 in “Human Pathology” This review discusses the implications of deterministic chaos in pathology, emphasizing its potential impact on predicting biological behavior of lesions, and reports no new experimental results.
25 citations
,
April 2007 in “Journal of The American Academy of Dermatology” This article introduces the term "anisotrichosis" to describe the significant variation in hair shaft diameters observed in pattern alopecia, drawing a parallel to anisocytosis seen in blood smears, but reports no new research findings.
25 citations
,
March 2014 in “Experimental Dermatology” Leptin helps start the growth phase of hair.
23 citations
,
December 2006 in “Evaluation and Program Planning” This article presents a model for evaluating public R&D that emphasizes measuring capacity-based metrics over traditional outcome-based metrics, using the concept of a Knowledge Value Collective.
22 citations
,
October 2011 in “Bone” This study found that androgen signaling has complex effects on bone formation in male AR3.6-transgenic mice, with varying impacts based on the embryonic lineage of cells.
21 citations
,
March 2015 in “Journal of The American Academy of Dermatology” In this study, five out of six patients treated with vemurafenib for metastatic melanoma experienced hair loss, which improved after topical steroid treatment.
21 citations
,
August 2014 in “Journal of Cell Communication and Signaling” This study found that Tsukushi facilitates wound healing in mice by regulating macrophage function and myofibroblast differentiation.
20 citations
,
October 2018 in “Clinical Drug Investigation” This study observed that men receiving dutasteride for benign prostatic hyperplasia did not show significant differences in neuropsychological assessments compared to a control group not on dutasteride.
19 citations
,
July 1990 in “Cleveland Clinic journal of medicine” This article reviews endocrine therapies for androgen excess disorders, emphasizing spironolactone, estrogen, and dexamethasone as effective treatments; it reports no new clinical results.
17 citations
,
May 2021 in “Journal of Assisted Reproduction and Genetics” This study reviews the mechanisms by which SARS-CoV-2 may impact male fertility, noting potential disruptions in spermatogenesis and hormone secretion, and underscores the need for follow-up in recovered men.
17 citations
,
October 2006 in “Molecular and Cellular Endocrinology” This study found that the L457(3.43)R mutation in the human luteinizing hormone receptor increases phosphodiesterase activity, reducing hormonal response despite elevated basal cAMP levels.
16 citations
,
January 2016 in “Journal of Investigative Dermatology” This study found that IL-6 knockout mice exhibited increased wound-induced hair neogenesis compared to wild-type mice, likely due to enhanced STAT3 activation facilitated by compensatory cytokine activity.
16 citations
,
January 2012 in “Indian Journal of Endocrinology and Metabolism” This case series describes six women with both PCOS and Graves' disease, suggesting a possible shared underlying cause for their co-occurrence.
15 citations
,
March 2014 in “Biochimica and biophysica acta. Molecular and cell biology of lipids” This review discusses the role of acyl-CoA binding protein (ACBP) in the epidermal barrier, noting that its disruption in mice is linked to skin and fur abnormalities; it reports no new clinical results.
15 citations
,
November 2015 in “Trends in biotechnology” This article discusses strategies for changing hair color by regulating target genes in hair follicles using advanced delivery systems, but it reports no new experimental findings.
14 citations
,
July 2021 in “Biomedicines” This review discusses the roles of platelets in hemostasis and wound repair, the preparation methods for platelet concentrates, and their therapeutic applications in medicine and dentistry, reporting no new clinical results.
14 citations
,
October 2020 in “Scientific reports” This study found that ATM protein plays a crucial role in protecting human hair follicle melanocytes from oxidative stress, which is linked to the greying of hair.
14 citations
,
August 2012 in “Clinics in Dermatology” This review discusses the pathogenesis, epidemiology, clinical features, histology, and treatment of frontal fibrosing alopecia and reports no new clinical results; the authors highlight its increasing incidence and challenging nature.