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Stem cell niches support, regulate, and coordinate stem cell functions.

Guidelines for diagnosing common hair loss include detailed history, clinical examination, and various diagnostic techniques.

Patients with certain skin symptoms and high ANA titers should be monitored for potential systemic lupus.

Alopecia areata is a common autoimmune disease affecting about 2% of people, causing significant disability and often associated with mental health issues and other autoimmune conditions.

Aging causes skin stem cells to work less effectively.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Obesity worsens PCOS symptoms, and PCOS may lead to more weight gain; managing both requires a holistic approach that includes mental health.

The document concludes that while significant progress has been made in understanding skin biology and stem cells, more research is needed to fully understand their interactions with their environment.

People with PCOS, especially if obese, often have NAFLD, linked to obesity, insulin resistance, and high androgen levels.

New single-cell analysis techniques are improving our understanding of stem cells and could help in treating diseases.

A WNT10A gene mutation leads to ectodermal dysplasia by disrupting cell growth and differentiation.

Mutations in the PADI3 gene are linked to a higher risk of scarring hair loss in women of African descent.

The EDAR gene greatly affects hair thickness in Asian populations.

TNF family proteins are crucial for the development of skin features like hair, teeth, and mammary glands.

Mutant mice help researchers understand hair growth and related genetic factors.

Animal models have helped understand hair loss from alopecia areata and find new treatments.

Despite progress, better treatments and understanding are needed for the high rates of long-term issues and deaths linked to eating disorders.

White lupin uses specific genes to grow root hairs and access phosphorus when it's scarce.

Muscles and nerves that cause goosebumps also help control hair growth.

Cells in hair follicles help create fat cells in the skin by releasing a protein called Sonic Hedgehog.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Tiny needles with valproic acid can effectively regrow hair.

People with alopecia areata often have lower levels of vitamin D, zinc, and folate, but more research is needed to understand if supplements can help treat it.

The study showed that hair follicle stem cells can maintain and organize themselves in a lab setting, keeping their ability to renew and form hair and skin.

Lymphocytes, especially CD8+ T cells, play a key role in causing alopecia areata, and targeting them may lead to new treatments.

Certain proteins, caspases-1 and -11, are important in the early development of skin inflammation in mice.

SHBG may be a useful early indicator and treatment target for PCOS.

Products should be called 'sperm-safe' only after thorough, well-designed tests.

The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.

Tofacitinib was effective in treating hair loss in two patients with alopecia universalis.