Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that silencing IGFBP5 reduced neurotoxicity and motor deficits in the 6-OHDA model of Parkinson's disease, likely by affecting the SHH signaling pathway, suggesting its potential role in mitigating Parkinson’s-related neuronal damage.

In this study, researchers found that the microRNA miR-1199-5p may reduce the expression of SRD5A2 in benign prostatic hyperplasia tissues, potentially contributing to the failure of 5-α reductase inhibitor therapy in some patients.

This review discusses the role of stem cells and tissue engineering in regeneration and transplantation, emphasizing the need for advanced technologies to improve treatments for injuries and disabilities, but reports no new results.

This review discusses the structural properties, pharmacological effects, and clinical applications of neurotoxins on synapses, reporting no new experimental results.

This study found that women with polycystic ovary syndrome have higher body mass index, fat mass percentage, and skinfold thickness compared to women without PCOS.

This article reviews the role of testosterone in sexual health, supporting Testosterone Replacement Therapy as an effective treatment for Hypoactive Sexual Desire Disorder in postmenopausal women, though more research is needed on its long-term effects and applicability to premenopausal women.

This case highlights the importance of considering syphilis testing for patients with unusual symptoms like hair loss and hypopigmentation, emphasizing the diagnostic and management challenges in resource-limited settings.

This narrative review suggests a strong association between abrupt hormonal imbalances and frontal fibrosing alopecia in women, especially related to reduced fertile years and certain hormonal therapies.

In this study, onion (Allium cepa) extracts promoted hair growth in an alopecia model in mice, with the effect appearing unrelated to the presence of the polyphenol quercetin.

This review highlights significant research trends and challenges in utilizing plant-derived extracellular vesicles for drug delivery and biomedical applications, emphasizing the need for standardized protocols and advanced purification technologies.

This review discusses the role of LGR4 in tumors, highlighting its involvement in cancer progression, metastasis, and chemotherapy resistance, as well as its regulatory effects on tumor stem cell self-renewal and stem cell characteristics, based on multiple recent studies.

This study detected insomnia risk signals associated with various medications, primarily nervous system drugs, using the FDA's Adverse Event Reporting System data from 2004 to 2024.

This review covers the diverse clinical applications of platelet-rich plasma in regenerative medicine but provides no new clinical results.

This scoping review reports that while empirical evidence suggests an overlap between Long/Post Covid-19 syndrome, chronic fatigue syndrome, and fibromyalgia, the underlying molecular mechanisms remain unclear, highlighting the need for standardized definitions and rigorous methodologies in Long Covid research.

In this study, low concentrations of DMSO were found to decrease androgen receptor expression and inhibit the migration of prostate cancer cells, suggesting potential as an anticancer therapy.

This study found that long-term use of dutasteride in men taking it for androgenetic alopecia may lead to persistent decreases in semen volume and sperm motility, potentially impacting fertility, with significant impairment observed after 17.8 to 20.3 months of treatment.

This study observed a marked increase in syphilis frequency within the studied population in 2020, along with dynamic patterns of clinical manifestations and increasing re-infection rates.

This research paper reviews the mechanisms and management of non-biologic immunosuppressive drugs used in dermatology, highlighting their safety profiles and handling during pregnancy, breastfeeding, and vaccination, but does not report specific results on these aspects.

This study investigated medications potentially linked to male-factor infertility using the FDA Adverse Event Reporting System and found that finasteride, testosterone, valproate, and other drugs showed significant disproportionate reporting of infertility cases, highlighting a potential under-reporting issue to regulatory bodies.

This study reviewed early research on topical finasteride for androgenetic alopecia, finding it appears safe and promising, though further investigation is needed to determine optimal dosing, frequency, and potential applications for other types of alopecia.

This study reports isolated clitoral hood hair-thread tourniquet syndrome, highlighting the importance of suspicion in females with prominent clitoral hood and genital pain to facilitate timely intervention and tissue preservation.

This case study provides an exemplar of a 75-year-old man with metastatic renal cell carcinoma, outlining his medical history, recent imaging findings, and treatment decisions; it reports no clinical results.

This case report describes a rare instance of multiple sebaceous cysts over the scrotum in a 22-year-old man, highlighting the effectiveness of ultrasound imaging for diagnosis and the need for surgical intervention in severe cases.

This review discusses case reports of autoimmune diseases following vaccination and the challenges of establishing a clear epidemiological connection, urging further investigation into vaccine-induced autoimmunity.

This study indicated that abnormal Bmp signaling in β-catenin gain-of-function mutants is associated with anorectal malformations, shedding light on potential mechanisms underlying these congenital conditions.

This review explores regenerative treatment options for non-scarring alopecia, with a focus on the potential of mesenchymal stem cells for hair regrowth, but it reports no new clinical results.

This study categorizes the human fetal vaginal epithelium into four areas with distinct transcriptomic profiles, aiding potential advancements in vaginal reconstruction and drug delivery.

This review highlights recent progress in developing androgen receptor degraders, such as PROTACs, for treating castration-resistant prostate cancer, and notes that several have entered phase I or II clinical trials, showcasing potential to address drug resistance challenges.

This case report found that the most likely cause of the patient's seizures and brain tumor was prior radiation exposure, with seizures managed effectively using intravenous lorazepam and subsequent treatment for the brain mass.

This study found that despite androgen excess and genitourinary masculinization, adult women with congenital adrenal hyperplasia did not exhibit notable prostatic growth.