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Lithocholic acid helps hair growth and regeneration in alopecia by activating vitamin D receptors.

The vitamin D receptor has many roles in the body beyond managing calcium, affecting the immune system, hair growth, muscles, fat, bone marrow, and cancer cells.

The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.

Targeting colon cancer stem cells might lead to better treatment results.

The document concludes that mouse models are helpful but have limitations for skin wound healing research, and suggests using larger animals and genetically modified mice for better human application.

Vitamin D receptor interacts with certain dietary components to help prevent diseases and regulate hair growth.

Estrogens can improve skin aging but carry risks; more research is needed on safer treatments.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

Blood vessels and specific genes help turn cartilage into bone when bones heal.

Mice hair growth patterns get more complex with age and can change with events like pregnancy or injury.

MIM is crucial for hair follicle formation and regeneration by controlling cilia formation and hedgehog signaling through its interaction with Cortactin and Src.

The p75 neurotrophin receptor is important for hair follicle regression by controlling cell death.

Skin has specialized touch receptors that can tell different sensations apart.

Stress hormone corticosterone blocks a growth factor to slow down hair stem cell activity and hair growth.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

The conclusion is that hair growth can be improved by activating hair cycles, changing the surrounding environment, healing wounds to create new hair follicles, and using stem cell technology.

Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.

Beta-caryophyllene helps improve wound healing in mice, especially in females.

Melanocyte development from neural crest cells is complex and influenced by many factors, and better understanding could help treat skin disorders.

People with alopecia areata often have lower levels of vitamin D, zinc, and folate, but more research is needed to understand if supplements can help treat it.

The research found how GPCR Class A Rhodopsin receptors are related and suggested possible substances they interact with.

Brain hormones significantly affect hair color and could potentially be used to prevent or reverse grey hair.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

Cannabinoids may help treat chronic and chemotherapy-induced neuropathic pain, but more research is needed to confirm their effectiveness and safety.

Wnt signaling is important for development and cell regulation but can cause diseases like cancer when not working properly.

The document concludes that future heart disease research should account for sex-specific differences to improve diagnosis, treatment, and outcomes.

CYLD mutations cause a variety of skin tumors with symptoms starting around age 16, and treatments are currently limited.

Damaging mitochondrial DNA in mice speeds up aging due to increased reactive oxygen species, not through the p53/p21 pathway.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Bergamot may improve heart health, skin conditions, and mood, but more research is needed to confirm these benefits.