This research review concluded that 5α-reductase inhibitors may be effective in treating androgenetic alopecia, showing general efficacy over placebo, though future clinical trials are needed to determine the best drug, dose, and duration, as well as gender differences in treatment response.
July 2022 in “DOAJ (DOAJ: Directory of Open Access Journals)” This narrative review explores the efficacy and side effects of medical treatments for androgenetic alopecia, focusing on minoxidil, 5-alpha-reductase inhibitors, low light laser therapy, and platelet-rich plasma, and discusses potential variations in response based on gender and the effectiveness of combination therapies.
September 2023 in “Clinical, Cosmetic and Investigational Dermatology” This study found a significant negative correlation between serum SHBG levels and androgenetic alopecia severity in women, but not in men, while no significant correlation was observed for testosterone, estradiol, dehydroepiandrosterone sulfate, and vitamin D levels with hair loss severity across genders.
This study found that certain dietary changes, such as a low glycemic load diet for men and specific supplements for women, may improve acne, while chocolate, whey proteins, and dairy products are linked to worsened symptoms in both genders.
88 citations
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September 2003 in “Clinical endocrinology” This review discusses the diagnosis, management, and hormone treatment of transsexual individuals, and examines the risks and effects of cross-sex hormone therapy without presenting new clinical results.
November 2021 in “Research Outreach” Low testosterone levels may lead to more severe COVID-19 outcomes.
186 citations
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February 2015 in “Frontiers in Neuroscience” This review discusses the complex effects of testosterone on the brain, emphasizing sex differences, and reports no clinical results; the authors highlight the inconsistencies in current study findings.
1 citations
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December 2013 in “Journal of pharmacy and pharmaceutical sciences” This study concluded that vitamins and protein tablets were more effective for reducing hair fall than shampoos and other medications, while herbal oils were preferable to chemical-based hair fall solutions.
October 2024 in “International Journal of Biology Pharmacy and Allied Sciences” In this research, a thorough review of hair loss issues and treatments identified the effectiveness of minoxidil and finasteride for alopecia in the scalp's vertex region, but noted concerns about their potential long-term effects, leading to increased interest in herbal therapies.
October 2023 in “Dermatology practical & conceptual” In this review, the authors evaluated the potential of using the second to fourth digit ratio (2D:4D) as a predictor for androgenetic alopecia, suggesting future research directions but not reporting definitive results.
185 citations
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August 2020 in “Mayo Clinic Proceedings” This review discusses biological sex differences in COVID-19 outcomes and reports no new clinical results; it identifies a need for studies to clarify how sex influences disease progression.
August 2025 in “Food Science and Technology” In this review, the authors discuss the potential benefits of black soybeans and white ferula mushroom for preventing hair loss, highlighting the need for ongoing research to identify effective dietary ingredients for maintaining hair health.
October 2023 in “Research Square (Research Square)” This study demonstrated that polynucleotide gel injections effectively reduced hair shedding and increased hair thickness in both men and women with androgenetic alopecia, while maintaining a high safety profile and patient satisfaction.
October 2022 in “Hair Transplantation” This paper reviews hair restoration surgery options for transgender patients and reports no new clinical results; the authors emphasize tailoring treatment plans to individual facial features and hair characteristics.
8 citations
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October 2017 in “Dermatologic Surgery” This review discusses male-specific techniques for botulinum toxin application to enhance aesthetic treatment outcomes in men and reports no new clinical results.
5 citations
,
January 2012 in “JBI Library of Systematic Reviews” This review discusses the fermented wheat germ extract Avemar as a potential adjunctive therapy in cancer treatment, noting promising laboratory results, but reports limited human trial evidence for its clinical effectiveness.
1 citations
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January 2020 in “Elsevier eBooks” Hormone therapy is safe and effective for transgender adults, but requires regular monitoring and mental health support.
November 2023 in “Plastic and Reconstructive Surgery – Global Open” This survey reported that Americans often view hair loss as affecting their attractiveness and consider hair transplantation a valuable option, with women willing to pay more than men despite being less likely to undergo the procedure.
This article discusses how modern lifestyle changes, such as stress and poor diet, contribute to hair loss in younger generations, with hair thinning often leading to alopecia; it emphasizes the need for hair root activation to promote hair growth and prevent loss.
August 2025 in “Галицький медичний вісник” This study examines the pathogenetic mechanisms and morphological changes in androgenetic alopecia, highlighting the role of genetic and hormonal factors like dihydrotestosterone in hair follicle changes, which is crucial for developing effective diagnostics and treatments.
162 citations
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October 2014 in “Autoimmunity reviews” This review discusses alopecia areata, highlighting its autoimmune aspects, environmental triggers, and current treatment options, but reports no new clinical results; recent studies suggest JAK pathway intervention may offer therapeutic potential.
41 citations
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January 2011 in “Nippon Ishinkin Gakkai Zasshi” This study identified the clinical aspects and dermatophyte types involved in tinea incognito in Iran, with Trichophyton verrucosum being the most frequently isolated species among affected patients.
34 citations
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October 2017 in “Archivos Argentinos De Pediatria” This review discusses the clinical characteristics, diagnosis, and treatment of alopecia areata, exploring potential environmental, immunological, and genetic factors involved in its development, but reports no new research findings.
27 citations
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May 2016 in “Dermatologic Surgery” This review examines how male facial anatomy and behavior contribute to sexual dimorphism in facial aging, pointing to factors that accelerate aging in men but presents no new clinical results.
19 citations
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August 2018 in “International Journal of Dermatology” In this study, lupus panniculitis of the scalp was associated with a high incidence of recurrence and progression to systemic lupus erythematosus, despite various treatments showing complete response within weeks.
16 citations
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July 2018 in “Experimental Dermatology” This study suggests that the transcription factor Gata6 plays a role in maintaining the structure of the upper hair follicle and may be implicated in conditions marked by its abnormal expansion, such as acne or cystic diseases.
15 citations
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April 1960 in “Journal of the American Medical Association” This article discusses cultural perspectives on hirsutism and hypertrichosis and reports no new clinical results.
14 citations
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January 2015 in “Hormones and Cancer” This study found that androgen receptor inactivation in male and female mice reduced susceptibility to DMBA-induced skin cancer, but the effect varied by the carcinogenesis model.
10 citations
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August 2020 in “Dermatologic Therapy” This study found that platelet-rich plasma significantly increased hair diameter in both men and women with androgenetic alopecia but improved hair density only in men.
9 citations
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November 2017 in “Dermatologic Clinics” This article reviews botulinum toxin use in men, focusing on anatomical and treatment differences, with no new clinical results.