329 citations
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January 1997 in “Journal of the American Academy of Dermatology” This study reports that progressive frontal fibrosing alopecia, a distinct and gradually stabilizing form of lichen planopilaris affecting elderly women and often involving eyebrow hair loss, lacks effective treatments.
January 2025 in “Cancer Cell Research” In this study, the researchers analyzed traditional Chinese medicine treatments for hair loss, concluding that conditions such as liver and kidney deficiencies contribute to alopecia and suggesting herbal treatments like Platycladus orientalis and Polygonum multiflorum for therapy.
August 2023 in “JAAD Case Reports” This report describes a 57-year-old woman with fibrosing alopecia in a pattern distribution, who experienced hair regrowth with combined treatment including hydroxychloroquine and other topical and oral therapies.
7 citations
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January 2018 in “International Journal of Trichology” Taking 5 mg/day finasteride can cause side effects in women with hair loss, but these are usually mild and fade over time, making the treatment beneficial in the long run.
September 2021 in “Zenodo (CERN European Organization for Nuclear Research)” This article discusses the global interest and market presence of biotin-based supplements like Folexin for preventing alopecia, but it reports no new research findings.
November 2023 in “International Journal of Pharmaceutics” This study reported that a novel ionic liquid delivery system combining ferulic acid and finasteride enhanced the solubility, skin permeation, and effectiveness in promoting hair regrowth in androgenetic alopecia mice, suggesting an improved topical treatment approach.
This study reviews female hair loss conditions with a focus on diagnosis and treatment. It highlights female pattern hair loss as the most common form and emphasizes the need for personalized therapy, including topical minoxidil and, when appropriate, antiandrogen treatments.
6 citations
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May 2022 in “Chemistry & biodiversity” This study identified compounds from Laportea bulbifera with potential inhibitory effects on human steroid 5α-reductase 2, suggesting their application in treating benign prostatic hyperplasia.
20 citations
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January 2014 in “Journal of the European Academy of Dermatology and Venereology” This article includes no new results; it discusses ongoing treatment approaches for frontal fibrosing alopecia and lichen planopilaris.
November 2012 in “Annales de Dermatologie et de Vénéréologie” This report describes the first known pediatric cases of frontal fibrosing alopecia, a condition typically affecting postmenopausal women, highlighting its occurrence in children including female twins.
22 citations
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April 2012 in “Informa Healthcare eBooks” This study reports two cases of frontal fibrosing alopecia in postmenopausal women, suggesting it as a variant of lichen planopilaris due to similar histological findings yet distinct clinical presentation.
March 2026 in “Dermatology and Therapy” This prospective study observed that low-dose oral minoxidil improved anterior hairline and eyebrow coverage in adult women with frontal fibrosing alopecia and was generally well-tolerated.
16 citations
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January 2017 in “Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia” This case study discusses a postmenopausal woman's frontal fibrosing alopecia and lichen planus pigmentosus, controlled with corticosteroids and finasteride, highlighting diagnostic and therapeutic challenges in scarring alopecia.
123 citations
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August 2005 in “Journal of the European Academy of Dermatology and Venereology” In this study, the researchers observed that treatment with intralesional and topical corticosteroids, finasteride, and minoxidil may stop the progression of frontal fibrosing alopecia in postmenopausal and premenopausal women.
30 citations
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November 2008 in “Facial Plastic Surgery” This review discusses hair transplant techniques for female pattern hair loss and reports no new clinical results; it highlights the benefits of transplants combined with various treatments for improved hair density and styling options.
July 2021 in “British Journal of Dermatology” In this study, the researchers reported that early diagnosis and treatment of fibrosing alopecia in a pattern distribution may arrest or potentially reverse disease progression, though some patients experienced continued hair loss.
49 citations
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January 2003 in “Clinical and Experimental Dermatology” This report from the UK reviews the literature on post-menopausal frontal fibrosing alopecia and highlights its under-recognition and distinctive characteristics compared to lichen planopilaris, but does not provide new results.
19 citations
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June 2010 in “Journal of acupuncture and meridian studies” This study found that emodin from Polygonum multiflorum showed 5alpha-reductase inhibitory activity, which was more potent than alizarin but less potent than riboflavin.
3 citations
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January 2011 in “Journal of biologically active products from nature” This study found that the polyherbal formulation F1, containing five traditional herbs, significantly enhanced hair growth in terms of length and thickness, suggesting potential for alopecia treatment.
April 2023 in “Journal of Investigative Dermatology” This study suggests that linalool, a common allergen in personal care products, may contribute to frontal fibrosing alopecia pathogenesis by triggering immune responses and depleting hair follicle stem cells, especially in sensitized individuals.
57 citations
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October 2013 in “international journal of endocrinology and metabolism” This review discusses clinical features, differential diagnosis, and treatments for female pattern hair loss, emphasizing the use of 2% topical Minoxidil and exploring alternative off-label therapies.
89 citations
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February 2002 in “Australasian journal of dermatology” This case report describes the first known instance of fibrosing alopecia associated with cutaneous lichen planus, suggesting fibrosing alopecia may be a variant of lichen planopilaris.
30 citations
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March 2011 in “Australasian Journal of Dermatology” This case report found that a woman's hair loss, which progressed while using spironolactone and topical minoxidil, reversed after switching to flutamide therapy.
December 2023 in “Natural product research” This study found that compound 4 from Urtica triangularis subsp. pinnatifida exhibited stronger anti-BPH activity against BPH-1 cells with an IC50 of 79.75 μM compared to finasteride's IC50 of 91.8 μM, while compounds 1, 2, and 5 showed moderate activity.
13 citations
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January 2023 in “Frontiers in Nutrition” This review explored the chemical makeup and pharmacological effects of Lindera aggregata, identifying 349 components including sesquiterpenoids, flavonoids, and alkaloids, with various potential benefits demonstrated in vitro and in vivo, such as anti-inflammatory and antioxidant effects.
20 citations
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January 2016 in “Intractable & Rare Diseases Research” In this clinical experience, treating frontal fibrosing alopecia with oral finasteride, hydroxychloroquine, tacrolimus, and excimer laser was associated with optimal results in patients with active inflammation.
1 citations
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October 2008 in “Expert Review of Dermatology” This review discusses frontal fibrosing alopecia, noting its frequent misdiagnosis and highlighting the need for larger studies to better understand its epidemiology, causes, and treatment options; it reports no new clinical findings.
December 2018 in “International journal of women’s dermatology” This case report highlights that frontal fibrosing alopecia may be underrecognized in young women and notes that no single treatment regimen has been proven consistently effective for this condition.
June 2020 in “Medicina estética” This review compiles recent scientific evidence and insights on female pattern hair loss for aesthetic physicians, but it reports no new clinical results.
15 citations
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July 2020 in “Dermatologic Therapy” This review discusses the pathophysiology, diagnosis, systemic associations, and treatments for female pattern hair loss and reports no new clinical findings.