Treatment of Frontal Fibrosing Alopecia and Lichen Planopilaris

    January 2014 in “ Journal of the European Academy of Dermatology and Venereology ”
    Matthew Harries, Andrew G. Messenger
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    TLDR The critique highlights an error in a review about hair loss treatment, stressing the need for accurate information and caution due to poor evidence quality.
    The document discusses a critique of a study by Racz et al. on the treatment of frontal fibrosing alopecia (FFA) and lichen planopilaris. The critique, by Harries and Messenger, points out an error in Racz et al.'s review regarding the effectiveness of oral finasteride treatment for FFA. Racz et al. had reported a 'partial response' in a series of 16 patients with FFA treated with finasteride, but Harries and Messenger clarify that only 7 of those 16 were actually treated with finasteride, and the main treatment was intralesional triamcinolone acetonide. All patients except one followed this treatment and saw a halt in hair loss progression over 24 months. The critique emphasizes the need for caution when interpreting the limited literature on FFA, noting that the quality of evidence is poor and treatment outcomes are often imprecise and subjective. They also highlight the importance of accurate study representation in reviews to aid clinicians in making informed treatment decisions.
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      in Research/Science  81 upvotes 1 year ago
      The conversation is about the role of testosterone in hair loss and the effectiveness of different treatments. The conclusion is that DHT is the main culprit for hair loss, and finasteride has been proven to work long-term in maintaining and regrowing hair. Testosterone may have a minor effect, but it is not the primary cause of hair loss.
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      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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      in Research/Science  14 upvotes 9 months ago
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