In these randomized, placebo-controlled trials, patients with alopecia areata who received baricitinib showed significantly higher eyebrow and eyelash hair regrowth rates compared to placebo, with greater responses observed at the 4 mg dose and in those achieving overall scalp hair improvement by Week 52.
January 2021 in “Türkiye klinikleri dermatoloji dergisi” This study found that eyebrow involvement in frontal fibrosing alopecia was more common among postmenopausal females with comorbidities, without a significant link to age or disease duration.
October 2024 in “Dermatology Practical & Conceptual” This study found that trichoscopy is a valid and sensitive tool for diagnosing and evaluating eyebrow involvement in lichen planopilaris and frontal fibrosing alopecia.
October 2025 in “Indian Dermatology Online Journal” In this case report, an elderly woman was diagnosed with tinea capitis and eyebrow involvement, which was initially misdiagnosed as alopecia areata, illustrating the importance of trichoscopy in correctly identifying this infection even in uncommon sites like the eyebrow.
April 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” This study examined clinical characteristics of lichen planopilaris and frontal fibrosing alopecia in 24 men, revealing common scalp symptoms, frequent beard involvement, and limited association with thyroid disease.
October 2024 in “La Tunisie Médicale” In this cross-sectional study conducted at Farhat Hached Hospital in Tunisia, more than half of the 60 alopecia areata patients surveyed experienced depression, particularly younger individuals and those with severe or specific forms of the condition, underscoring the need for psychological support.
17 citations
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June 2024 in “Journal of the European Academy of Dermatology and Venereology” This study suggests that using an appropriate tool for measuring quality of life is vital, particularly as factors like severity, female sex, and eyebrow involvement may increase the psychosocial burden of alopecia areata.
November 2023 in “Indian Journal of Dermatology” This study from North-East India analyzed 21 cases of frontal fibrosing alopecia, noting a high prevalence in post-menopausal women and distinct histological features such as perifollicular lymphocytic infiltrate and hydropic degeneration.
86 citations
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January 2020 in “British Journal of Dermatology” This study developed the Alopecia Areata Investigator Global Assessment (AA-IGA) to measure scalp-hair loss in alopecia areata patients, incorporating perspectives of both patients and clinicians to define treatment success.
9 citations
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January 2020 in “Postepy Dermatologii I Alergologii” This review discusses the enigmatic nature of frontal fibrosing alopecia and reports no clinical results; the authors stress the need for further research.
August 2025 in “American Journal of Clinical Dermatology” This vodcast discusses various tools for assessing the severity of alopecia areata, emphasizing the importance of considering psychosocial impacts alongside physical symptoms.
June 2023 in “British Journal of Dermatology” This study observed that baricitinib treatment led to significant improvements in hair regrowth and quality of life scores in adults with severe alopecia areata over 24 weeks, with an acceptable safety profile as most adverse effects were transient.
July 2018 in “Elsevier eBooks” This review discusses the evolving understanding of frontal fibrosing alopecia as a generalized skin condition with diverse manifestations, and reports no new clinical results.
January 2015 in “Journal of evolution of medical and dental sciences” In this study, topical tacrolimus 0.03% cream showed good to excellent response in treating alopecia areata in 70% of participants, with no cutaneous or systemic side effects observed.
January 2012 in “Yearbook of Dermatology and Dermatologic Surgery” Alopecia areata is a hair loss condition that often starts before age 30 and can affect various body parts, with unpredictable hair regrowth chances.
74 citations
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April 2017 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” This study classified frontal fibrosing alopecia patients into three clinical patterns, finding that pattern III had the best prognosis and pattern II the worst after treatment with dutasteride and corticosteroids.
7 citations
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October 2015 in “Actas Dermo-Sifiliográficas” This article reviews the increasing incidence of frontal fibrosing alopecia since its first description in 1994 and reports no new results.
November 2024 in “SKIN The Journal of Cutaneous Medicine” In this study, NH Asian alopecia areata patients reported the highest levels of severe disease, with NH White patients having the most eyebrow involvement and Hispanic patients showing the least severity.
April 2023 in “World Journal Of Advanced Research and Reviews” This study in Morocco found that all women with frontal fibrosing alopecia presented frontotemporal hairline recession, with trichoscopic features such as perifollicular erythema and follicular hyperkeratosis being indicative of the condition, and suggested a potential link between cosmetic products or emotional factors and the disease.
This study reported that prompt diagnosis and treatment with 5-alpha-reductase inhibitors and topical immunomodulators are key to mitigating the effects of frontal fibrosing alopecia and preventing permanent hair loss.
2 citations
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July 2025 in “Advances in Therapy” In this study, patients with more severe self-reported hair loss and emotional or social limitations experienced lower quality of life and greater work productivity impairment, with even moderate hair loss causing significant well-being and daily activity impacts.
21 citations
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October 2017 in “Journal of the European Academy of Dermatology and Venereology” This study reports that variable environmental factors, including dietary habits, may contribute to the increasing incidence and diverse clinical presentations of frontal fibrosing alopecia.
11 citations
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November 2018 in “Journal of the American Academy of Dermatology” This study found that among patients with alopecia areata treated with the JAK inhibitor tofacitinib, 34% achieved complete regrowth of eyebrows and 39% achieved complete regrowth of eyelashes, highlighting differences in treatment responses across hair-bearing sites.
14 citations
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January 2014 in “Indian Journal of Dermatology Venereology and Leprology” Frontal fibrosing alopecia can affect men's beards and leads to permanent hair loss.
January 2025 in “Medical Research Archives” This study found that alopecia areata often affects beard hair as frequently as scalp hair, leading the authors to propose a new scoring system and a subtype called alopecia subuniversalis for extensive hair involvement.
1 citations
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February 2025 in “Journal of the American Academy of Dermatology” Most men prefer keeping their eyebrows over scalp hair.
17 citations
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January 2015 in “International Journal of Trichology” This case report suggests that frontal fibrosing alopecia with nail involvement may be associated with lichen planus and improved with oral dutasteride due to an inflammatory reaction related to androgenetic alopecia.
November 2025 in “SKIN The Journal of Cutaneous Medicine” In this study on adolescents with severe alopecia areata, baricitinib treatment showed effective scalp, eyebrow, and eyelash regrowth after 52 weeks, benefiting both responders and partial or non-responders, potentially reducing the psychosocial impact of the disease.
September 2025 in “Journal of the American Academy of Dermatology” Eyebrow and eyelash hair loss in alopecia areata worsens quality of life.
October 2024 in “Journal of Cutaneous Immunology and Allergy” This case report describes a successful treatment of sarcoidal foreign body reactions caused by permanent makeup ink with local steroid injections, while also identifying the involvement of M2 macrophages in the reaction.