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DHEA did not improve sexual function, well-being, or menopausal symptoms in postmenopausal women with low libido but caused side effects like acne and increased facial hair.

Overweight women with PCOS have higher levels of certain hormones that could indicate a higher risk of heart and metabolic problems.

Metformin taken during pregnancy increases SHBG in newborns but doesn't change other hormone levels in mothers or babies.

Testosterone may slow down wound healing and increase inflammation.

Menopause reduces skin collagen and elasticity, and while estrogen therapy can help, its risks require careful consideration.

Women's ovarian hormones and adrenal androgens change throughout life, affecting hair loss and health.

Testosterone replacement can help women with low libido and mood, but they need to have enough estrogen first to avoid side effects.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

Some hormone-related drugs may protect brain cells in Parkinson's disease differently in men and women.

Steroid sulfatase is important for activating hormones that affect memory, brain function, and certain diseases, and could be a target for treating hormone-related disorders.

The document suggests that blocking sweat glands with antiperspirants might allow skin-generated hormones to be absorbed, possibly increasing breast and prostate cancer risk.

The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Non-hormonal treatments should be used first for sexual dysfunction in postmenopausal breast cancer patients on aromatase inhibitors, with hormones as a second option.

Minoxidil breakdown varies by enzymes, affecting hair loss treatment effectiveness.

Sex steroids produced in the hippocampus are crucial for brain functions like memory and learning in rodents.

Statins may help treat PCOS by lowering androgen levels and improving cholesterol.

Vitamin D and estrogen may help protect heart and kidney health, and maintaining sufficient vitamin D levels could be especially beneficial for African Americans, postmenopausal women, and people with chronic kidney disease.

The document concludes that understanding sulfation biology is crucial for creating treatments due to its importance in biological functions and disease.

A 5 mg dose of transdermal testosterone cream effectively restores testosterone levels in postmenopausal women.

A man had a rare stroke possibly due to taking finasteride, which might have increased his hormone levels causing a blood clot. His memory loss didn't fully recover even after stopping the medication.

Higher estrone-to-estradiol ratios are linked to worse glucose metabolism and insulin resistance in women with PCOS.

Men with advanced liver disease and high oestrone and low testosterone levels have worse health outcomes.

Oophorectomy lowers testosterone and estrogen levels in both premenopausal and postmenopausal women, with postmenopausal women still producing significant testosterone.

Aromatase inhibitors cause male pattern hair loss in women.

Hormone therapy for breast cancer often leads to sexual issues like vaginal dryness and decreased libido.

A 12-year-old boy with PAIS successfully developed male characteristics using high-dose testosterone and anastrozole.

Valproic acid, a common antiepileptic medication, can cause reversible hair loss in patients.

SHBG binding properties are unchanged in male liver cirrhosis patients.

The enzyme 17β-HSD type 2 mainly performs oxidation in human sebaceous glands, which may help protect against acne.