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The conclusion is that PCOS is caused by ovarian sensitivity to hormones and disrupted hormone control, possibly due to ovarian factors, and more research is needed.

Smoking harms the skin, causing early aging and increasing cancer risk, but stopping smoking can improve skin health.

Edible seeds from the Cucurbitaceae family like pumpkin and watermelon seeds are nutritious and may have health benefits, but eating too much can cause side effects.

CRAC channels are crucial for the development and function of specialized immune cells, preventing severe inflammation and autoimmune diseases.

Blocking CRF-R1 can reduce alcohol intake in stressed mice.

Androgen is important in controlling stem cell differentiation, reducing fat development, and increasing lean mass.

Some hormone-related drugs may protect brain cells in Parkinson's disease differently in men and women.

New resveratrol-related compounds show promise for treating various health issues but need more research for clinical use.

The document concludes that there is a significant lack of reporting on the sex and age of cells in skin research, which could affect clinical trials and treatments.

Scientists have developed a new method to detect steroid abuse in athletes using cell-based tests, which could be the future of anti-doping methods.

Researchers found new potential treatments for conditions related to the androgen receptor, like male hormonal contraception, by testing thousands of compounds.

Blocking the Mitochondrial Pyruvate Carrier causes stress in hair follicles, which can be reduced by an ISR inhibitor.

Blocking glucocorticoid receptors improves glucose metabolism in a PCOS mouse model.

The 2003 consensus updated PCOS diagnosis criteria and highlighted increased risks of diabetes and heart disease for those affected.

The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.

The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

Testosterone is important for men's sexual function, may help some women's sexual desire, while other hormones and neurotransmitters also play complex roles in sexual behavior.

Certain proteins, Lgr5 and Lgr6, are important markers of adult stem cells and are involved in tissue repair and cancer development.

Chemicals and body size might change when puberty starts and progresses, but more research is needed to confirm this.

Vitamin D receptor interacts with certain dietary components to help prevent diseases and regulate hair growth.

The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.

Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.

Chemotherapy causes hair loss by damaging hair follicles and stem cells, with more research needed for prevention and treatment.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Estrogen therapy can reduce skin aging but has cancer risks.

Vitamin D is important for skin health and may affect conditions like psoriasis and hair loss, but more research is needed to understand its role fully.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.