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    Did you mean Enzyme Inhibition?
    Glossary Enzyme Inhibition

    reduction or cessation of enzyme activity by specific molecules

    Enzyme inhibition refers to the process by which the activity of an enzyme is reduced or stopped. This can occur through various mechanisms, such as competitive inhibition, where an inhibitor molecule competes with the substrate for the active site, or non-competitive inhibition, where the inhibitor binds to a different part of the enzyme, altering its shape and function. Understanding enzyme inhibition is crucial in fields like pharmacology and biochemistry, as it can influence drug design and metabolic regulation.

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    1. Enzyme Inhibitors from Gorgonians and Soft Corals Marine Drugs · 2023 · 4 citations
    2. Enzyme-linked immunosorbent assays for doping control of 5α-reductase inhibitors finasteride and dutasteride Analytica Chimica Acta · 2010 · 10 citations
    3. The enzyme and inhibitors of 4-ene-3-oxosteroid 5α-oxidoreductase Steroids · 1995 · 64 citations
    4. pH STIMULUS-RESPONSIVE HYBRID NANOPARTICLES: A SYSTEM DESIGNED FOR FOLLICULAR DELIVERY OF BRAZILIAN PLANT-DERIVED 5-ALPHA-REDUCTASE ENZYME INHIBITORS International Journal of Pharmaceutics · 2023
    5. Effect of the 5α-reductase enzyme inhibitor dutasteride in the brain of intact and parkinsonian mice 2017 · 16 citations
    6. Role of DNA Methylation in the Pathogenesis of Skin Disorders: Mechanisms, Inhibitors of Methylation‐Related Enzyme, and Molecular Docking Studies BioMed Research International · 2025
    7. Activity of steroid 4 and derivatives 4a–4f as inhibitors of the enzyme 5α-reductase 1 Bioorganic & medicinal chemistry · 2018 · 3 citations
    8. Nipple Differentiation in Fetal Male Rats Treated with an Inhibitor of the Enzyme 5<i>α</i>-Reductase: Definition of a Selective Role for Dihydrotestosterone* Endocrinology · 1986 · 53 citations
    9. Treatment of male rats with finasteride, an inhibitor of 5alpha-reductase enzyme, induces long-lasting effects on depressive-like behavior, hippocampal neurogenesis, neuroinflammation and gut microbiota composition Psychoneuroendocrinology · 2018 · 37 citations
    10. Inhibition of Human Steroid 5β-Reductase (AKR1D1) by Finasteride and Structure of the Enzyme-Inhibitor Complex Journal of Biological Chemistry · 2009 · 47 citations
    11. Staphylococcus aureus accessory gene regulator quorum-sensing system inhibits keratinocyte lipid enzymes and delays wound repair Journal of Clinical Investigation · 2025 · 1 citations
    12. Synthesis of mimics of steroid A ring as potential enzyme inhibitors Research Repository (Kingston University London) · 2002
    13. Finasteride, a 5alpha-reductase enzyme inhibitor, alone and synergism with a neurosteroid reduces responsiveness to nociceptive stimuli in male rat Journal of Pain · 2009
    14. Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride: Enzyme-Catalyzed Formation of NADP−Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor Journal of the American Chemical Society · 1996 · 136 citations
    15. Recent Advances in the Chemistry and Pharmacological Activity of New Steroidal Antiandrogens and 5α-Reductase Inhibitors Current Medicinal Chemistry · 2005 · 20 citations
    16. Synthesis and Study of Some 17a-aza-D-homo Steroids as 5α-Reductase Inhibitors Current Drug Discovery Technologies · 2020 · 1 citations
    17. Sulfotransferases, sulfatases and formylglycine-generating enzymes: a sulfation fascination Current Opinion in Chemical Biology · 2008 · 83 citations
    18. Estrogen regulates the expression of retinoic acid synthesis enzymes and binding proteins in mouse skin Nutrition research · 2021 · 3 citations
    19. Steroidogenic enzymes in skin. PubMed · 2001 · 21 citations
    20. The antimycotic agent clotrimazole inhibits melanogenesis by accelerating ERK and PI3K-/Akt-mediated tyrosinase degradation Experimental Dermatology · 2015 · 15 citations
    21. Fruit Acid Inhibits UV-Induced Skin Aging via PI3K/Akt and NF-κB Pathway Inhibition Discovery Medicine · 2025 · 3 citations
    22. ACE2 Inhibits Dermal Regeneration Through Ang II in Tissue Expansion Journal of Cosmetic Dermatology · 2025 · 1 citations
    23. Steroidal 5α-reductase and 17α-hydroxylase/17,20-lyase (CYP17) inhibitors useful in the treatment of prostatic diseases The Journal of Steroid Biochemistry and Molecular Biology · 2013 · 51 citations
    24. Novel 5α-Reductase Inhibitors:  Synthesis, Structure−Activity Studies, and Pharmacokinetic Profile of Phenoxybenzoylphenyl Acetic Acids Journal of Medicinal Chemistry · 2005 · 18 citations
    25. The Dark Side of 5α-Reductase Inhibitors' Therapy: Sexual Dysfunction, High Gleason Grade Prostate Cancer and Depression Korean Journal of Urology · 2014 · 75 citations
    26. Mimosine Dipeptide Enantiomsers: Improved Inhibitors against Melanogenesis and Cyclooxygenase Molecules · 2015 · 25 citations
    27. Synthesis and biological evaluation of novel unsaturated carboxysteroids as human 5α-reductase inhibitors: A legitimate approach European journal of medicinal chemistry · 2012 · 17 citations
    28. Novel C-6 substituted and unsubstituted pregnane derivatives as 5α-reductase inhibitors and their effect on hamster flank organs diameter size Steroids · 2009 · 15 citations
    29. Chronic Restraint Stress Inhibits Hair Growth via Substance P Mediated by Reactive Oxygen Species in Mice PLoS ONE · 2013 · 76 citations
    30. Aqueous extract of Asiasari radix inhibits formalin-induced hyperalgesia via NMDA receptors Journal of Ethnopharmacology · 2009 · 17 citations