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    Did you mean Enzyme Inhibition?
    Glossary Enzyme Inhibition

    reduction or cessation of enzyme activity by specific molecules

    Enzyme inhibition refers to the process by which the activity of an enzyme is reduced or stopped. This can occur through various mechanisms, such as competitive inhibition, where an inhibitor molecule competes with the substrate for the active site, or non-competitive inhibition, where the inhibitor binds to a different part of the enzyme, altering its shape and function. Understanding enzyme inhibition is crucial in fields like pharmacology and biochemistry, as it can influence drug design and metabolic regulation.

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    1. Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride: Enzyme-Catalyzed Formation of NADP−Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor Journal of the American Chemical Society · 1996 · 136 citations
    2. Potency of a novel saw palmetto ethanol extract, SPET-085, for inhibition of 5α-reductase II Advances in Therapy · 2010 · 46 citations
    3. Determination of the potency of a novel saw palmetto supercritical CO2 extract (SPSE) for 5α-reductase isoform II inhibition using a cell-free in vitro test system Research and reports in urology · 2016 · 3 citations
    4. Recent Advances in the Chemistry and Pharmacological Activity of New Steroidal Antiandrogens and 5α-Reductase Inhibitors Current Medicinal Chemistry · 2005 · 20 citations
    5. Determination of the potency of a novel saw palmetto supercritical CO2 extract (SPSE) for 5α-reductase isoform II inhibition using a cell-free in vitro test system DOAJ (DOAJ: Directory of Open Access Journals) · 2016 · 2 citations
    6. Inhibition of rat α-reductases by finasteride: Evidence for isozyme differences in the mechanism of inhibition The Journal of Steroid Biochemistry and Molecular Biology · 1997 · 98 citations
    7. Enzyme Inhibitory Activities of Marine Sponges Against Cholinesterase and 5α-Reductase 2019
    8. Pharmacological Inhibition of Stearoyl CoA Desaturase in the Skin Induces Atrophy of the Sebaceous Glands 2013 · 25 citations
    9. In Vivo Time-Dependent Inhibition of Human Steroid 5a-Reductase by Finasteride Journal of Pharmaceutical Sciences · 1996 · 29 citations
    10. FCE 28260, a new 5α-reductase inhibitor: In vitro and in vivo effects The Journal of Steroid Biochemistry and Molecular Biology · 1996 · 17 citations
    11. 2-Substituted 4-(Thio)chromenone 6-<i>O</i>-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase Journal of Medicinal Chemistry · 2002 · 111 citations
    12. Mimosine Dipeptide Enantiomsers: Improved Inhibitors against Melanogenesis and Cyclooxygenase Molecules · 2015 · 25 citations
    13. Clinical Pharmacokinetics and Pharmacodynamics of Finasteride Clinical Pharmacokinectics · 1996 · 93 citations
    14. Modulating testosterone pathway: a new strategy to tackle male skin aging? Clinical Interventions in Aging · 2012 · 6 citations
    15. Effect of C-ring modifications in benzo[c]quinolizin-3-ones, new selective inhibitors of human 5α-reductase 1 Bioorganic & Medicinal Chemistry · 2001 · 12 citations
    16. Design, synthesis and structure-activity relationships studies on steroidal aromatase and 5α-reductase inhibitors as anti-tumors Estudo Geral (Universidade de Coimbra) · 2013
    17. Exploring the Inhibitory Potential of Phytosterols β-Sitosterol, Stigmasterol, and Campesterol on 5-Alpha Reductase Activity in the Human Prostate: An In Vitro and In Silico Approach Plants · 2024 · 12 citations
    18. Inhibition of 17α-hydroxylase/C17,20 lyase reduces gating deficits consequent to dopaminergic activation Psychoneuroendocrinology · 2013 · 19 citations
    19. Molecular interactions of natural and synthetic steroids in female hamsters’ flank organs Journal of Dermatological Science · 2012 · 1 citations
    20. Synthesis and 5α-reductase inhibitory activity of 8-substituted benzo[ƒ]quinolinones derived from palladium mediated coupling reactions Bioorganic & Medicinal Chemistry Letters · 1998 · 14 citations
    21. Inhibition of skin 5α-reductase by oral contraceptive progestins<i>in vitro</i> Gynecological Endocrinology · 2000 · 78 citations
    22. Evaluating Carthamus Oxyacantha For 5α-Reductase Inhibition: Therapeutic Perspectives In BPH Journal for ReAttach Therapy and Developmental Diversities · 2023
    23. Determination of rat 5α-reductase type 1 isozyme activity and its inhibition by novel steroidal oxazolines Acta Biologica Hungarica · 2010 · 4 citations
    24. Steroid Sulfatase: Molecular Biology, Regulation, and Inhibition Endocrine Reviews · 2005 · 451 citations
    25. Exploring the Potential of Eclipta alba: A Promising Approach for Hair Treatment Management through 5-Alpha Reductase Inhibition International journal of pharmaceutical quality assurance · 2023
    26. In vitro 5α-reductase inhibition by selected Ayurvedic herbs for androgenic disorders International Journal of Ayurveda Research · 2024
    27. Allopregnanolone is required for prepulse inhibition deficits induced by D1 dopamine receptor activation Psychoneuroendocrinology · 2019 · 12 citations
    28. Phospholipase A<sub>2</sub> inhibition as potential therapy for inflammatory skin diseases Immunotherapy · 2013 · 13 citations
    29. Physiopathological role of the enzymatic complex 5α-reductase and 3α/β-hydroxysteroid oxidoreductase in the generation of progesterone and testosterone neuroactive metabolites Frontiers in Neuroendocrinology · 2020 · 18 citations
    30. Enzymes British Journal of Pharmacology · 2008