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The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

The conclusion is that using drugs to block the TOR pathway might slow aging and prevent age-related diseases.

Exposure to too much androgen before birth might cause polycystic ovary syndrome later in life.

Two main types of fibroblasts with unique functions and additional subtypes were identified in human skin.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Interferon alfa-2a is effective for treating cutaneous T cell lymphoma but has significant side effects.

A new microneedle patch made from hair proteins helps regrow hair faster and better than current treatments.

Wnt signaling controls whether hair follicle stem cells stay inactive or regenerate hair.

Oestrogens are key for bone growth during puberty in both boys and girls.

CDP is crucial for lung and hair follicle cell development.

The new "differential stripping" method effectively measures how much substance gets into hair follicles.

New research suggests that skin cell renewal may not require a special type of cell previously thought to be essential.

Congenital Adrenal Hyperplasia is a genetic disorder with two forms, causing symptoms like early puberty and severe acne, but can be identified through screening and treated with glucocorticoids.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

Sonic hedgehog signaling is crucial for hair growth and maintaining hair follicle identity.

Most women with hirsutism or androgenic alopecia had polycystic ovaries, especially if they had irregular periods.

The conclusion is that PCOS is caused by ovarian sensitivity to hormones and disrupted hormone control, possibly due to ovarian factors, and more research is needed.

Obesity worsens PCOS symptoms, and PCOS may lead to more weight gain; managing both requires a holistic approach that includes mental health.

Oxidative stress contributes to hair graying and loss as we age.

The document concludes that understanding hair structure is key to diagnosing hair abnormalities and recommends gentle hair care for management.

Diffuse alopecia in women may be related to androgens and iron deficiency, and basic hormone and nutrient screening is useful.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

People with PCOS, especially if obese, often have NAFLD, linked to obesity, insulin resistance, and high androgen levels.

Aminopterin strongly suppresses epithelial tissues and can treat certain skin conditions but has significant side effects.

Cyproterone acetate-estrogen most effective for hirsutism, but consider side effects and patient needs.

More men are getting benign prostatic hyperplasia, and there are many treatments, from medication to surgery, with new methods being developed.

Foals with Rhodococcus equi infection often have other health problems that lower their chances of survival.

Recombinant cytokine therapy can cause skin reactions ranging from mild to severe.