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Accurate quantitative bioanalysis using LC-MS/MS is challenging due to matrix effects, but using internal standards and new methods like in-sample calibration could improve results.

Different substances that activate or block the androgen receptor can affect male development and treat conditions like prostate cancer.

Growth factor treatments are increasingly used in medicine but require more research to fully understand their mechanisms.

Early surgery reduces seizure risk in drug-resistant epilepsy; testosterone to DHT conversion doesn't affect muscle anabolism; veterans with PTSD likely to have riskier opioid use; bevacizumab helps in hereditary bleeding disorder.

Some people have a genetic variation that makes them less effective at breaking down drugs.

Cosmetic hair treatments can increase hair testosterone levels, while natural hair color does not affect it.

TLR2 is important for hair growth and can be targeted to treat hair loss.

Adequate vitamin D might lower, and high hair chromium might increase DNA damage in obese women.

Benzothiazepines like diltiazem reduce anxiety in mice by making neurosteroids.

Neuroactive steroids may affect the risk and treatment of alcohol use disorders.

The document concludes that managing health issues like menopause, cardiovascular risk, and hair loss is crucial for promoting longevity in aging women.

Some natural remedies may help with hair regrowth, but more research is needed to confirm their effectiveness and safety.

Hair follicles are important for drug delivery through the skin, but better methods are needed to understand and improve this process.

Activating STAT5 in the skin's dermal papilla is key for starting hair growth, regenerating hair follicles, and healing wounds.

Skin aging reflects overall body aging and can indicate internal health conditions.

Testosterone therapy can improve sexual function in women but long-term safety is unclear.

Finding functions for unknown GPCRs is hard but key for making new drugs.

Scientists successfully created and analyzed the structure of a part of the human androgen receptor with specific modulators and a peptide to understand how it binds differently in various tissues.

New therapies for burn wounds show promise in reducing pain, infection risk, and improving healing and physical outcomes.

Vitamin B supplements may reverse grey hair.

Premature graying of hair is common and stressful, but not well understood or treated.

ADAM17 could be a potential target for treating PCOS.

Scientists made a mouse that shows how a specific protein in the skin changes and affects hair growth and shape.

PPAR-γ may be a key target for treating alopecia areata and other skin conditions.

Thiocyanate helps hair growth and can be supplemented in diet or applied topically.

Oxidative stress is linked to mild patchy alopecia areata.

Segmental hair analysis can track testosterone over time but needs adjustments for sex, hair color, and washing frequency.

Oral tranexamic acid is a safe and effective treatment for melasma.

The new microscope method helps study energy from pre-cancerous skin cells.

PRP helps heal and repair tissues in medicine but needs more research for better use.