Oral Low-Dose Naltrexone in the Treatment of Frontal Fibrosing Alopecia and Lichen Planopilaris: An Uncontrolled Open-Label Prospective Study

    January 2023 in “ Curēus
    Remi K. Hamel, Ling Chen, Cailin O’Connell, Caroline Mann
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    Studysummary In this study, low-dose naltrexone significantly reduced erythema in patients with frontal fibrosing alopecia and lichen planopilaris after one year, but no significant improvements were seen in other symptoms. Our plain-language summary of this paper — not a Tressless recommendation.
    This study investigated the use of low-dose naltrexone (3 mg daily) as adjunctive therapy for frontal fibrosing alopecia (FFA) and lichen planopilaris (LPP) in 26 patients over one year. Results showed a significant decrease in erythema at 12 months compared to baseline, with a mean reduction of 0.93 on a 0-3-point scale (p<0.0001). However, there were no significant changes in pruritus, burning/pain, or scalp involvement. The study suggests that low-dose naltrexone may be beneficial for treating erythema in FFA and LPP, though further research is needed due to limitations such as small sample size and concurrent medications.
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