Pharmacological Application of Growth Factors: Basic and Clinical

    January 2015 in “ BioMed Research International ”
    Jian Xiao, Yadong Wang, Savério Bellusci, Xiaokun Li
    Image of study
    TLDR Growth factor treatments are increasingly used in medicine but require more research to fully understand their mechanisms.
    The document discusses the pharmacological application of growth factors in both basic research and clinical settings. Growth factors, which are signaling molecules secreted at repair sites by various cell types, play a crucial role in cell growth, differentiation, proliferation, wound healing, and tissue regeneration. The editorial mentions that treatment with growth factors is becoming more prevalent, especially in plastic and reconstructive surgery, but the molecular mechanisms of such treatments are not fully understood, necessitating further research. The special issue includes eight papers from researchers in four countries, covering topics such as the potential of nerve growth factor (NGF) in treating glaucoma, the anti-tumor and antiangiogenic potential of tryptase inhibitors, the neuroprotective efficacy of neurotrophins, and the promotion of hair growth by fibroblast growth factors (FGFs). One study highlighted is by L.-J. Xiang et al., which found that FGFs can induce the anagen phase in resting hair follicles of telogenic C57BL/6 mice, suggesting potential as a hair growth-promoting agent. The issue aims to contribute to the understanding of growth factors and the development of new therapeutic drugs.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Comprehensive Microneedling Guide

      in Microneedling  290 upvotes 2 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

      community Verteporfin and Microneedling

      in Treatments 6 months ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

      community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

      in Research/Science  743 upvotes 2 years ago
      A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

    Similar Research

    6 / 1000+ results