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A rare endocrine disorder, APS 1, was diagnosed in a 26-year-old man in Bangladesh.

PCOS is a hormonal disorder causing infertility and menstrual problems, often linked to obesity and can lead to acne, treated with hormonal and insulin-sensitizing medications.

A new method can almost perfectly distinguish adenomyosis from similar conditions using blood tests.

The vitamin D receptor has many roles in the body beyond managing calcium, affecting the immune system, hair growth, muscles, fat, bone marrow, and cancer cells.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

The modified Ferriman-Gallwey method is a useful tool for diagnosing hirsutism.

The report recommends personalized treatment for women's sexual dysfunctions and more research on effective therapies.

Melatonin may benefit skin health and could be a promising treatment in dermatology.

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

South Asian women with PCOS are more likely to have metabolic issues and central obesity, and simple measures like waist size and blood pressure can help identify these risks early.

The document concludes that certain genetic mutations and dietary factors are involved in acne development, and treatments like isotretinoin and diet changes can help manage it.

Vitiligo is linked to autoimmune diseases and hearing issues, so hearing tests are recommended for patients.

Coats' Plus is a genetic disorder with eye abnormalities, brain calcification, poor growth, bone and skin issues, and movement disorders.

Fat cells are important for healthy skin, hair growth, and healing, and changes in these cells can affect skin conditions and aging.

Platelet-rich plasma may help in skin and hair treatments, and with muscle and joint healing, but more research is needed to fully understand its benefits and limitations.

The circadian clock influences the behavior and regeneration of stem cells in the body.

Many young women who donate blood have hormonal disorders like excess male hormones and PCOS.

ADT, especially enzalutamide, may increase the risk of heart rhythm problems and sudden death in men.

The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.

Dienogest combined with ethinylestradiol is a highly effective birth control that improves menstrual symptoms and has manageable side effects.

Adults with polycystic ovary syndrome are much more likely to have obstructive sleep apnea.

Genetic screening is crucial for accurately diagnosing APS-1 due to its varied symptoms.

A position effect on the TRPS1 gene causes excessive hair growth in humans and mice.

The document suggests treating individuals with nonclassic congenital adrenal hyperplasia who show symptoms, especially those related to excess male hormones.

Antidepressants, 5α-reductase inhibitors, and isotretinoin can cause long-lasting sexual dysfunction.

Metformin has limited effectiveness for improving PCOS symptoms and lacks clear benefits, needing more research to confirm its efficacy.

Insulin resistance linked to obesity may increase COVID-19 severity.