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Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.

Minoxidil treats hair loss, promotes growth, has side effects, and has recent patents.

Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

Humans lost body hair relatively recently in evolution.

Superficial granulomatous pyoderma is a unique, mild form of skin disease that often heals without strong medication and responds well to milder treatments.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

Antiandrogens are somewhat effective in reducing excessive hair growth in women.

Minoxidil boosts hair growth by increasing cell production and survival.

Trilostane effectively improved symptoms in dogs with a certain adrenal gland disorder.

Most people with systemic lupus erythematosus have skin problems, and skin symptoms are often the first sign of the disease.

Cathepsin L is essential for normal hair growth and development.

K_ATP channel gene mutations are linked to heart diseases, but more research is needed to understand the connection and treatment potential.

Lupus affects the body and skin, causing joint pain and skin issues that can be treated with steroids and antimalarial drugs.

Generalized pustular psoriasis patients often need strong medication and careful treatment due to flare-ups and complications.

Androgens, like testosterone, are crucial for early testicular descent in rats.

The document concludes that a better understanding of cell changes during wound healing could improve treatments for chronic wounds and other conditions.

Taxane chemotherapy can cause skin, hair, and nail side effects, which are often under-reported and can affect patient quality of life.

The enzyme 25 Hydroxyvitamin D 1 α-Hydroxylase is essential for healthy skin and recovery after skin damage.

Transplant success has improved with better immunosuppressive drugs and donor matching.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Estrogen replacement can improve skin health in menopausal women but doesn't reverse sun damage or prevent hair loss.

Estrogen loss during menopause worsens skin health, but hormone replacement therapy may improve it, though more research is needed.

Turmeric may have benefits for skin health, but more research is needed to confirm its effectiveness.

Exosomes could potentially enhance tissue repair and regeneration with lower rejection risk and easier production than live cell therapies.

Higher levels of unbound testosterone are linked to increased insulin resistance, especially in women with polycystic ovary syndrome.

Adam10 enzyme is crucial for healthy skin and proper Notch signaling.

In Italian patients with lupus, the most common skin issue was chronic cutaneous lupus, especially discoid lesions, and nonspecific skin problems occurred in about a third of those with systemic lupus, mainly during active disease.

Modulating BMP activity changes the number, size, shape, and type of ectodermal organs.

Macrophages help heal nerves by aiding the maturation of Schwann cells and are important for nerve repair.

Mouse hair follicle cells briefly grow during the early hair growth phase, showing that these cells are important for starting the hair cycle.