research A Regulatory Perspective on Pharmacokinetic/Pharmacodynamic Modelling
The document concludes that PK/PD modeling is important for determining the safe and effective dosages of drugs.
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research Antidepressant-Like Effect of Fluoxetine May Depend on Translocator Protein Activity and Pretest Session Duration in Forced Swimming Test in Mice
Fluoxetine's effectiveness as an antidepressant in mice depends on a specific protein activity and a 5-minute pretest.
research Cocaine-Related Bullous Disease
Cocaine use can cause a blistering skin disease.
research The Case for Case Reports
Case reports are important in medical science for discovering drugs and identifying rare conditions, despite their limitations.
research Human Hair Follicle Organ Culture: Theory, Application, and Perspectives
Human hair follicle organ culture is a useful model for hair research with potential for studying hair biology and testing treatments.
research Cognitive and Mood Side Effects of Lower Urinary Tract Medication
Some medications for bladder problems can cause memory issues or mood changes, and doctors should monitor these side effects.
research Adverse Effects of Opioid Analgesic Drugs
Opioid painkillers can cause many side effects, including breathing problems and addiction, but are generally considered safe when used properly.
research Network-Based Drug Repositioning: Approaches, Resources, and Research Directions
The document concludes that computational methods using networks and various data can improve the process of finding new uses for existing drugs.
research Effects of Dermatological Medications on Male Fertility
Some dermatological medications can impair male fertility, so consult a doctor before trying to conceive.
research GABRA2 Alleles Moderate the Subjective Effects of Alcohol, Which Are Attenuated by Finasteride
GABRA2 gene variations impact alcohol response, and hair loss medication finasteride reduces some effects.
research Effects of Finasteride on Chronic and Acute Ethanol Withdrawal Severity in the WSP and WSR Selected Lines
Finasteride reduces alcohol withdrawal severity and anxiety in mice, but may increase withdrawal severity in some cases.
research Bipolar Disorders and Valproate: Pharmacokinetics, Pharmacodynamics, Therapeutic Effects, and Indications of Valproate: Review of Articles
Valproate is a mood stabilizer for bipolar disorder but has side effects and risks, especially during pregnancy.
research Spotlight Commentary: Importance of Dose Redefining in the Process of Drug Repurposing
Redefining drug dosages is crucial when repurposing them for new uses.
research Comparative Effects of Finasteride and Minoxidil on Male Reproductive Organs: A Systematic Review of In Vitro and In Vivo Evidence
Finasteride is more harmful to male reproductive health than minoxidil.
research Monoclonal Antibody Against Prolactin Receptor: A Randomized Placebo-Controlled Study Evaluating Safety, Tolerability, and Pharmacokinetics of Repeated Subcutaneous Administrations in Postmenopausal Women
The drug BAY 1158061 is safe, well-tolerated, and shows potential for treating diseases related to prolactin.
research Impact of Alpha Blockers, 5-Alpha Reductase Inhibitors, and Combination Therapy on Sexual Function
Medications for enlarged prostate can cause sexual side effects like reduced libido, erectile dysfunction, and ejaculatory problems.
research A Gender Hypothesis of Sex Disparities in Adverse Drug Events
Gendered social factors, not just biology, contribute to sex differences in adverse drug events.
research Sex Differences in Opioid-Mediated Effects: Role of Androgens
Men and women react differently to opioids, with hormones potentially influencing these differences.
research Comparison of Therapeutic Effects of Finasteride Gel and Tablet in Treatment of Androgenic Alopecia
Finasteride gel and tablet both have similar moderate effects in treating male hair loss.
research Analysis of Adverse Drug Reactions in Pediatric Patients with Epilepsy: An Intensive Pharmacovigilance Study
Many pediatric epilepsy patients experience preventable severe adverse drug reactions, especially with certain medications and risk factors.
research Development of a Non-Parametric Population Pharmacokinetics Model and Bayesian Estimator for Tacrolimus in Tunisian Renal Transplant Patients
The model and estimator can predict drug exposure in kidney transplant patients well.
research Understanding Key Symptoms, Side Effects, and Impacts of HR+/HER2- Advanced Breast Cancer: Qualitative Study Findings
Patients with HR+/HER2- advanced breast cancer commonly experience fatigue, hair loss, and pain, which significantly affect daily activities.
research The Role of Androgen and Androgen Receptor in Skin-Related Disorders
Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.
research Rational Design of a Topical Androgen Receptor Antagonist for the Suppression of Sebum Production with Properties Suitable for Follicular Delivery
A new compound was created in 2010 that can control oil production when applied to the skin, and its effects are completely reversible after two weeks.
research The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men
Dutasteride and finasteride may reduce sperm count and volume but don't affect movement or shape; effects are reversible after stopping.
research Corticosteroids for the Treatment of Duchenne Muscular Dystrophy
Corticosteroids, especially prednisone, improve short-term muscle strength in Duchenne muscular dystrophy but have manageable side effects.
research Formulation and Optimization of Transfersome Containing Minoxidil and Caffeine
Minoxidil and caffeine in transfersomes improve hair growth treatment.
research Mechanism of Action of Isotretinoin
Isotretinoin effectively treats severe acne but can cause significant side effects like dry skin and hair loss.
research Oral Isotretinoin for Acne
Oral isotretinoin may slightly improve acne but increases the risk of side effects like dry lips and skin; more research is needed to understand its full risks and benefits.
research Tofacitinib Loaded Squalenyl Nanoparticles for Targeted Follicular Delivery in Inflammatory Skin Diseases
Tofacitinib nanoparticles can safely and effectively treat alopecia areata by targeting hair follicles.