July 2021 in “British Journal of Dermatology” Low testosterone levels may contribute to female pattern hair loss in men.
5 citations
,
February 2023 in “Frontiers in Veterinary Science” This study found that ovine dermal papilla cells exhibit robust aggregation and alkaline phosphatase activity, regulated by Wnt/β-catenin signaling, providing insights for improving wool performance and hair regeneration therapies.
96 citations
,
October 1987 in “The Journal of Clinical Endocrinology & Metabolism” This study found that long-term GnRH agonist administration in premenopausal women with polycystic ovarian disease resulted in persistent suppression of ovarian steroid secretion, while adrenal steroid levels remained unchanged.
52 citations
,
May 2013 in “Supportive Care in Cancer” Scalp cooling significantly reduces hair loss in chemotherapy patients.
18 citations
,
April 2011 in “International Journal of Molecular Medicine” This study found that dihydrotestosterone (DHT) regulates the degradation of p27 in MCF-7 breast cancer and OVCAR-3 ovarian cancer cells, involving SKP2 as a key factor.
January 2018 in “Springer eBooks” PDE inhibitors, especially PDE4 inhibitors like apremilast, are effective for certain inflammatory skin conditions but have side effects and can be costly.
3 citations
,
July 2018 in “Elsevier eBooks” This case report describes an elderly man with erosive pustular dermatosis of the scalp, who improved with potent topical corticosteroids followed by maintenance with topical tacrolimus.
9 citations
,
August 2018 in “Biomedical dermatology” This study found that topical administration of the TGFβ mimetic peptide DPS-1 stimulated hair growth in mice by promoting HDP cell proliferation and enhancing hair follicle morphology.
53 citations
,
January 2011 in “Diabetes” The study found that severe insulin resistance and premature diabetes are common in patients with PCNT genetic defects, primarily affecting those over four years old, while not impacting early insulin signaling in adipocytes.
9 citations
,
August 2023 in “Molecules” This study found that the peptides RMYYY and VMYMI displayed stronger binding energy and more frequent interactions with HPGDS compared to the native inhibitor, suggesting potential as future therapeutic drugs.
May 2024 in “Regenerative Therapy” This laboratory study found that dendrobium officinale polysaccharide (DOP) stimulated hair follicle and hair growth in mice by activating the WNT signaling pathway.
August 2025 in “DS Reviews of Research in Life Sciences” In this study, women with polycystic ovary syndrome showed significantly higher levels of DHEA, IL-6, and TNF-α compared to healthy controls, indicating a possible link between these biomarkers and PCOS.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that an E-cadherin mutant preserved normal cadherin levels and prevented inflammation and lethality in mouse skin lacking p120, highlighting p120's role in regulating cadherin-mediated cell adhesion and inflammation.
June 2019 in “Reactions Weekly” November 2010 in “International Journal of Developmental Neuroscience” September 2025 in “Global Journal of Pharmacy & Pharmaceutical Sciences” This review analyzes PDRN's molecular mechanisms and therapeutic applications in anti-aging dermatology but reports no new clinical results, highlighting the need for more standardized protocols and long-term evaluations.
4 citations
,
September 2024 in “BMC Cancer” In this prospective phase II clinical trial, researchers are investigating whether adding dutasteride to combined androgen blockade can improve the response rate and clinical outcomes for patients with androgen receptor-positive recurrent or metastatic salivary duct carcinoma.
18 citations
,
September 2016 in “International Journal of Molecular Sciences” This study reports that PDRN, commonly used for wound healing, may also have anti-melanogenesis and potential skin whitening effects in both experimental models and clinical settings.
This case study presented by the researchers describes the effective use of topical calcipotriene ointment in treating a 6-year-old girl with en coup de sabre scleroderma, resulting in normalization of the sclerotic skin, hair regrowth, and improved pigmentation.
1 citations
,
July 2025 in “BMC Medicine” The authors concluded that establishing and standardizing methods for data collection are crucial to improving PCOS diagnosis and research due to challenges observed in data harmonization across diverse international cohorts.
May 2025 in “The Journal of Rheumatology” This case report describes a 47-year-old woman with dilated cardiomyopathy as the first sign of primary antiphospholipid syndrome, highlighting the need for APS screening in similar patient presentations.
4 citations
,
February 2022 in “International Journal of Dermatology” This study observed that porocarcinoma exhibited a relatively low rate of local recurrence, nodal metastases, and mortality over a follow-up period exceeding five years.
26 citations
,
January 2016 in “Annals of Dermatology” This study found that Ecklonia cava polyphenols increased human dermal papilla cell proliferation and extended hair shaft length in vitro and ex vivo, suggesting potential as a therapeutic candidate for hair loss.
4 citations
,
October 2021 in “Journal of Clinical Medicine” This study found that individuals with heterozygous truncation-type variants in the *DSP* gene exhibit lower skin temperature and higher transepidermal water loss, with specific microscopic skin changes and pseudomonilethrix.
2 citations
,
January 2025 in “Frontiers in Pharmacology” In a rat model of benign prostatic hyperplasia, this study found that purple corn extract may improve symptoms by inhibiting prostate enlargement, reducing androgen receptor signaling, and exerting anti-inflammatory effects.
1 citations
,
July 2023 in “Clinical Cosmetic and Investigational Dermatology” In this report, a 54-year-old woman with familial dyskeratotic comedones showed slight improvement in skin lesions after topical retinoids and urea cream. This source also describes the first dermoscopic findings for this condition and reviews 21 previous cases.
1 citations
,
January 2002 in “PubMed” The researchers reported that both finasteride and PM-9 competitively inhibit the 5 alpha-reductase enzyme in P. crustosum broth.
February 2023 in “Scientific Reports” This study suggests that cold atmospheric microwave plasma treatment may promote hair renewal by activating β-catenin and YAP/TAZ signaling in human dermal papilla cells.
January 2024 in “International Journal of Trichology” In this laboratory study, researchers found that human platelet-rich plasma (hPRP) significantly improved the proliferation and hair-inductive capacity of human dermal papilla cells (hDPCs) compared to fetal bovine serum, suggesting hPRP as a potential substitute for FBS in expanding hDPCs for clinical hair regeneration therapies.
December 2020 in “International Journal of Research in Pharmaceutical Sciences” This review analyzes the mnemonic MY PCOS, exploring diagnosis and treatment strategies for the metabolic, cosmetic, and reproductive complications of polycystic ovary syndrome, without reporting new clinical findings.