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Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

Mice lacking the PPARγ gene in their fat cells had almost no fat tissue, severe metabolic problems, and abnormal development of other fat-related tissues.

Androgens can both increase and decrease hair growth in different parts of the body.

Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.

Androgens can help prevent memory problems caused by apoE4.

New effective scar treatments are urgently needed due to the current options' limited success.

Alopecia areata involves immune activation in the scalp, suggesting treatments targeting TH1, TH2, and IL-23 pathways.

Isotretinoin is highly effective in treating severe acne, rosacea, and gram-negative folliculitis.

Hair loss needs more research for better treatments.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Androgens can cause hair growth in some areas and hair loss on the scalp.

TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.

Understanding hair growth involves complex interactions between molecules and could help treat hair disorders.

Finasteride helps hair growth but may cause sexual side effects.

Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

Humans lost body hair relatively recently in evolution.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

The Sonic hedgehog pathway is crucial for new hair growth during mouse skin healing.

Cancer cells often have more copies of TERT and TERC genes, which helps them grow and could affect patient outcomes.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

K_ATP channel gene mutations are linked to heart diseases, but more research is needed to understand the connection and treatment potential.

Too much androgen can cause hair loss; finasteride may help.

Protoporphyrin IX is useful in cancer treatment but can cause health problems if not properly regulated.

Masculine facial features may not reliably indicate heritable health, and more research is needed.

Finasteride effectively blocks enzyme causing male pattern baldness.

GABRA2 gene variations impact alcohol response, and hair loss medication finasteride reduces some effects.

Different types of stem cells and their environments are key to skin repair and maintenance.

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.