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    Glossary DNA damage response

    cellular mechanisms detect and repair damaged DNA to maintain integrity

    The DNA damage response (DDR) is a complex network of cellular processes that detect and repair damage to the DNA, ensuring the integrity of the genetic material. When DNA is damaged by factors like UV radiation or chemicals, DDR mechanisms activate to either fix the damage or, if repair is not possible, trigger cell death to prevent the propagation of faulty DNA. This system is crucial for preventing mutations that could lead to diseases such as cancer.

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    1. DNA Damage Response Mediates Pressure Overload–Induced Cardiomyocyte Hypertrophy Circulation · 2019 · 42 citations
    2. Mdm2-p53 Signaling in Tissue Homeostasis and the DNA Damage Response: A Dissertation 2012
    3. DNA Damage, Checkpoint Responses, and Cell Cycle Control in Aging Stem Cells Else Kröner-Fresenius Symposia · 2012
    4. Deletion of vitamin D receptor with calcium sensing receptor in keratinocytes promotes epidermal tumorigenesis by limiting dna repair and oxidative stress response genes The Journal of Steroid Biochemistry and Molecular Biology · 2026
    5. LH Induces Murine Hair Loss through TRPC-Medicated Cell Aging Responses: Implications for Female Pattern Hair Loss Pathogenesis Journal of Investigative Dermatology · 2025
    6. Editor's evaluation: Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation-induced tissue damage 2021
    7. Montagna Symposium 2013—Light and Skin: How Light Sustains, Damages, Treats, Images and Modifies Skin Biology 2014 · 1 citations
    8. Profiling the Response of Human Hair Follicles to Ultraviolet Radiation Journal of Investigative Dermatology · 2009 · 53 citations
    9. Oxidative DNA Damage Accelerates Skin Inflammation in Pristane-Induced Lupus Model Frontiers in Immunology · 2020 · 48 citations
    10. Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss Cell Stem Cell · 2007 · 688 citations
    11. Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis Science · 2016 · 242 citations
    12. Replicative stress, stem cells and aging Mechanisms of Ageing and Development · 2008 · 70 citations
    13. Lamins in development, tissue maintenance and stress EMBO reports · 2012 · 64 citations
    14. Notch Signaling Regulates Late-Stage Epidermal Differentiation and Maintains Postnatal Hair Cycle Homeostasis PloS one · 2011 · 61 citations
    15. c-MYC-Induced Sebaceous Gland Differentiation Is Controlled by an Androgen Receptor/p53 Axis Cell reports · 2013 · 60 citations
    16. Vitamin D Receptor, UVR, and Skin Cancer: A Potential Protective Mechanism Journal of Investigative Dermatology · 2008 · 51 citations
    17. Hair follicle stem cell replication stress drives IFI16/STING-dependent inflammation in hidradenitis suppurativa Journal of Clinical Investigation · 2020 · 33 citations
    18. Intermittent treatment with farnesyltransferase inhibitor and sulforaphane improves cellular homeostasis in Hutchinson-Gilford progeria fibroblasts Oncotarget · 2017 · 32 citations
    19. CXXC5: A novel regulator and coordinator of TGF-β, BMP and Wnt signaling Journal of Cellular and Molecular Medicine · 2018 · 28 citations
    20. Expression of anti-aging type-XVII collagen (COL17A1/BP180) in hair follicle-associated pluripotent (HAP) stem cells during differentiation Tissue & Cell · 2019 · 11 citations
    21. Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis Journal of Dermatological Science · 2017 · 8 citations
    22. Molecular Insights into the Superiority of Platelet Lysate over FBS for hASC Expansion and Wound Healing Cells · 2025 · 2 citations
    23. Progeroide Syndrome Die Dermatologie · 2023 · 2 citations
    24. 559 Induction of tissue-specific premature stem cell aging promotes senescence-like phenotypes in remote multiple organs Journal of Investigative Dermatology · 2022
    25. QS8: Analysis of the Whole Transcriptome in Breast Cancer Patients Undergoing Radiotherapy and Breast Reconstruction Plastic and reconstructive surgery. Global open · 2021
    26. 244 Defective maintenance of hair follicle stem cells through COL17A1 loss orchestrates the hair follicle aging program Journal of Investigative Dermatology · 2017
    27. UV radiation, vitamin D and epidermal carcinogenesis Expert review of dermatology · 2009
    28. Loss of Stem Cells Correlates with Premature Aging in Animal Study, Penn Researchers Find Cancer biology & therapy · 2007
    29. Efficacy and Potential Mechanisms of Naringin in Atopic Dermatitis International Journal of Molecular Sciences · 2024 · 4 citations
    30. Local circadian clock gates cell cycle progression of transient amplifying cells during regenerative hair cycling Proceedings of the National Academy of Sciences of the United States of America · 2013 · 116 citations