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Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

TGF-β2 plays a key role in human hair growth and development.

Adding hyaluronic acid helps create larger artificial hair follicles in the lab.

No consistent link between genotype and phenotype in 5-α-Reductase type 2 deficiency.

SCF and c-Kit decrease in AGA hair follicles, possibly affecting hair pigmentation and growth.

Shorter CAG repeats in a specific gene may increase male hormone activity and symptoms like acne and excess hair in women with PCOS.

Early diagnosis and treatment are crucial for preventing permanent hair loss in various scalp conditions, and while new treatments are promising, more research is needed to evaluate their effectiveness.

Teriflunomide is an effective and generally safe oral treatment for relapsing MS, reducing relapses and slowing disability progression.

Fibromodulin treatment helps reduce scarring and improves wound healing by making it more like fetal healing.

Female pattern hair loss involves hormonal factors, genetics, and may be linked to low ferritin levels.

5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.

The conclusion is that accurately identifying the cause of high androgen levels in women with PCOS is crucial and requires specific tests.

The exact cause of increased 5α-reductase activity leading to hirsutism in women is still unknown.

Finasteride reduces alcohol withdrawal severity in male mice but increases it in female mice.

Tedisamil and glibenclamide affect cromakalim and minoxidil sulphate differently in rat aorta.

The document concludes that sexual and psychiatric side effects from 5-alpha-reductase inhibitors are reported, but more high-quality research is needed to understand how often they occur.

The conclusion is that measuring how drugs partition into artificial sebum is important for predicting their delivery into hair and sebaceous follicles, and it provides better information than traditional methods.

Cosmetics with hinokitiol-loaded nanocapsules were found to effectively promote hair growth.

Finasteride effectively treats male hair loss, improving growth and density.

The document concludes that managing hirsutism involves identifying the cause, using a scoring system for severity, combining cosmetic and medical treatments, encouraging weight loss, and providing psychological support, while noting the need for more research on drug treatments.

The document concludes that while lab results for hair growth promotion are promising, human trials are needed and better testing methods should be developed.

Early hair loss may indicate prostate issues.

Future osteoporosis treatments should focus on increasing bone growth, with many promising options available.

Women generally handle heart enlargement better than men, but it's riskier for them if it occurs; hormones like estrogen offer some protection.

Dutasteride protects dopamine neurons in Parkinson's mice, but Finasteride doesn't.

The document concludes that using LC-MS/MS for measuring androgens is more accurate than older methods, but it needs careful validation and standardized references to be most effective.

The document says that understanding the causes of PCOS is important for treatment, especially in distinguishing the syndrome from just having cystic ovaries, and that losing weight is key for obese women with PCOS.

Severe baldness on the top of the head is linked to a higher chance of heart disease, especially in men under 60.

17α-estradiol is a safe estrogen that might protect the brain and doesn't cause feminization, needing more research for treating brain diseases.