1 citations,
October 2022 in “International journal of endocrinology” Dihydrotestosterone changes some hormone-related gene expressions in rat pituitary glands but doesn't affect the estrous cycle.
15 citations,
April 2008 in “Steroids” The more lipophilic the progesterone derivative, the better it binds to androgen receptors and has antiandrogenic effects.
January 2022 in “Current Enzyme Inhibition” New nonsteroidal molecules can potentially increase dihydrotestosterone in neurons by blocking certain enzymes, without affecting prostate and seminal vesicle weight.
December 2023 in “Journal of the Endocrine Society” Blocking glucocorticoid receptors improves glucose metabolism in a PCOS mouse model.
51 citations,
January 2003 in “Hormone Research in Paediatrics” Hormones and their receptors, especially androgens, play a key role in hair growth and disorders like baldness.
April 2019 in “Journal of Investigative Dermatology” Testosterone affects androgen receptors and lipid storage in cells, while DHEA does not convert to testosterone or affect these receptors in the same way.
51 citations,
January 1989 in “Journal of Investigative Dermatology” Men with male-pattern baldness have more androgen receptors in their scalp's oil glands, which may contribute to hair loss.
31 citations,
April 2015 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” Androgens cause oil-producing skin cells with androgen receptors to mature and produce more oil.
12 citations,
January 2018 in “Pharmacology & pharmacy” Pumpkin seed products may help improve prostate and bladder health by blocking certain enzymes and hormone receptors.
29 citations,
November 1975 in “Clinics in endocrinology and metabolism” Testosterone is made by Leydig cells, is active when not bound to proteins, and works by binding to receptors in muscles and other tissues.
218 citations,
December 2011 in “Advances in Urology” The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.
209 citations,
September 2008 in “Dermatologic Therapy” Androgens can both increase and decrease hair growth in different parts of the body.
97 citations,
April 2016 in “Andrology” Hormones and metabolism play a complex role in prostate enlargement, and more research is needed to improve diagnosis and treatment.
59 citations,
September 2003 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” Epitestosterone may counteract testosterone's effects and has roles in body processes like prostate growth and hair distribution.
44 citations,
March 2012 in “Fitoterapia” Germacrone from Curcuma aeruginosa may help treat conditions related to male hormones by blocking a specific enzyme.
24 citations,
March 2003 in “Best Practice & Research Clinical Endocrinology & Metabolism” Androgens, male hormones, play a role in both men and women's health, and testosterone therapy can help women with low levels, but it's not suitable for pregnant or lactating women, or those with certain conditions.
23 citations,
May 1984 in “Journal of the American Geriatrics Society” Benign Prostatic Hyperplasia may be caused by changes in how the body processes male hormones.
19 citations,
March 1998 in “Endocrinology” Male rats have more somatostatin neurons than females due to testosterone converting to estrogen during early development.
11 citations,
May 2009 in “Medical Hypotheses” Male pattern baldness is an unintended side effect of the body's use of androgens for muscle growth, especially in those genetically prone to it.
3 citations,
November 2021 in “Journal of The American Academy of Dermatology” Androgenetic alopecia, a genetic disorder affecting up to 50% of adults, is caused by an excessive response to androgens leading to hair follicle shrinkage. Treatments include FDA-approved drugs, other therapies like low-dose oral minoxidil, and hair transplantation.
3 citations,
April 2015 in “American journal of biomedical sciences” Androgens play a key role in hair growth and disorders like baldness and excessive hairiness.
2 citations,
November 2008 in “Medical Hypotheses” VEGF and its receptor might cause hair loss.
1 citations,
May 2011 in “Journal of Human Reproductive Sciences” Finasteride may decrease semen quality but not harm sperm production, and stopping the drug can improve semen quality; hyperprolactinemia can cause infertility but is treatable with medication.
September 2023 in “Cureus” Topical finasteride might be a good alternative for hair loss treatment with fewer side effects, but more research is needed.
May 2023 in “Experimental Dermatology” Male pattern hair loss may be linked to the developmental origins of hair follicles.
Androgen receptor degrader drugs may be a promising future treatment for hair loss.
Androgenetic alopecia, or hair loss, is caused by a mix of genetics, hormones, and environment, where testosterone affects hair growth and causes hair to become smaller and grow for a shorter time.
March 2021 in “Bioscientia medicina” Androgen affects oil production and hair growth in the skin.
March 2021 in “Bioscientia medicina” Androgens like testosterone affect oil production and hair growth in skin and hair follicles.
February 2020 in “Definitions” 5 Alpha-Reductase Inhibitors reduce the effects of testosterone by blocking its conversion into a stronger form.