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This study found that among older men, lower calculated free testosterone was significantly associated with a higher risk of heart failure, suggesting a possible role of testosterone deficiency in heart failure incidence.

This research suggests that the enzyme Phospholipase D from E. coli is a strong candidate as the underlying cause of benign prostatic hyperplasia, potentially mediated by its conversion to lysophosphatidic acid in the prostate.

This study found that male pattern baldness may serve as a clinical marker for circulating sex hormone levels in men with localized prostate cancer, while chest hair density showed no significant hormone association.

This review discusses the role of androgens in women's sexual health and highlights the need for further research on androgen replacement therapy to optimize quality of life, but reports no new clinical results.

This study found that a polyherbal formulation of Trigonella foenum-graecum and Butea monosperma significantly promoted hair growth and reduced DHT levels in a chemotherapy-induced alopecia model.

This study found that spironolactone may improve acne and some ovarian functions in patients with irregular menstrual periods and androgenic symptoms, while causing few side effects.

This study found that in men, elevated androgen levels can occur at any age, with older men potentially exhibiting increased total testosterone due to higher levels of SHBG, and younger men showing various clinical manifestations like acne and alopecia.

This case report describes a 10-year-old twin boy with proximal hypospadias and undescended testis, highlighting the diagnostic and treatment evaluations for associated sex development disorders.

In this study, oral broccoli sprouts intake did not affect plasma androgen levels in males, while alfalfa sprouts intake increased testosterone and DHT levels, which may help prevent male late onset hypogonadism.

This review discusses treatments for androgenic alopecia, noting that current options like finasteride and minoxidil are effective for only 10% of patients, thus highlighting the need for new therapies.

Opioid use may lower PSA levels, suggesting a possible role in prostate cancer control; PSA testing is useful for detecting prostate cancer; serum triglycerides are not linked to prostate cancer risk; and higher urethral PSA levels may be associated with local hormone activity.

This study found that in female dogs, exposure to free fatty acids increased androgen production, suggesting a potential link to factors characteristic of polycystic ovary syndrome.

This review highlights a polyherbal hair formulation that combines various natural ingredients, reporting potential benefits in improving scalp circulation, strengthening hair, and promoting regrowth, which might offer a safer alternative for managing male pattern baldness compared to synthetic drugs.

The abstract for Roota Hair Growth describes a product combining botanical extracts with clinically-tested ingredients to target hair thinning, breakage, and scalp fatigue by blocking DHT, strengthening hair fibers, and revitalizing the scalp through a precision roll-on applicator, offering a natural alternative for healthier hair.

The investigators highlighted Roota Hair Growth as a promising botanical solution for hair concerns, suggesting it may improve hair health by addressing the root causes of thinning, breakage, and scalp fatigue.

This review found that circulating dihydrotestosterone (DHT) consistently distinguishes men with androgenetic alopecia from controls, suggesting a key role in the condition's biology and potential therapeutic targeting.

In this study, researchers examined men with early-stage androgenetic alopecia and found distinct patterns of hair loss correlated with genetic and hormonal factors, noting that parietal region pattern hair loss responded better to minoxidil and micronutrient treatment compared to occipital region pattern.

This case report discusses the diagnostic challenges and management options for three siblings with 46, XY DSD due to type 2 5-α reductase deficiency, highlighting the genetic basis and impact on their quality of life.

This study found that women with androgenic alopecia often have increased dihydrotestosterone levels, suggesting potentially enhanced activity of 5-alpha-reductase, with the saliva free testosterone level providing valuable hormonal background information.

In this study, men with persistent sexual dysfunction after stopping finasteride showed significant vascular, neurologic, and hormonal abnormalities, with severe erectile dysfunction being common.

Topical finasteride is promising for hair loss with minimal side effects but needs more research and approval.

This study reports that topical finasteride significantly reduced scalp and plasma dihydrotestosterone in men and women without altering serum testosterone levels, with promising preliminary results.

This study found that dual 5α-reductase inhibitors in rats decreased sperm quality and led to reduced pregnancy success, suggesting potential for use in male contraception.

This study showed that Thujae occidentalis semen extract inhibited 5alpha-reductase type 2 in laboratory tests and reduced androgen-related hair loss in animal models, suggesting potential use for male pattern baldness.

In this study, germacrone from Curcuma aeruginosa showed anti-androgenic effects by inhibiting 5α-reductase, suggesting its potential as a lead compound for treating androgen-dependent disorders.

This study found that dihydrotestosterone (DHT) regulates the degradation of p27 in MCF-7 breast cancer and OVCAR-3 ovarian cancer cells, involving SKP2 as a key factor.

This review summarizes recent advancements in steroidal 5α-reductase inhibitors for benign prostatic hyperplasia and reports no new clinical results.

This study suggests that hepatocellular carcinoma in cirrhotic men is associated with altered sex-steroid metabolism, indicated by lower testosterone and 5 alpha-dihydrotestosterone levels compared to cirrhosis alone.

In a retrospective cohort of patients with steroid 5 α-reductase 2 deficiency, this study identified seven novel genetic variants in the SRD5A2 gene, expanding the variant database and contributing to improved diagnostic and therapeutic approaches for the condition.

This study developed a validated gas chromatography–tandem mass spectrometry assay to assess sex steroid hormones in cerebrospinal fluid, finding substantial levels of DHEA, androstenedione, and testosterone, with strong correlations to serum levels, providing insight into sex steroid dynamics in the human CNS.