The Prevention of Benign Prostatic Hyperplasia (BPH)

The document discussed the role of the enzyme Phospholipase D (PLD) from Escherichia coli (E. coli) in causing benign prostatic hyperplasia (BPH). It highlighted that PLD stimulates the production of lysophosphatidic acid (LPA), which promotes the growth of prostatic smooth muscle and connective tissue, leading to BPH. The evidence for this infection-based process was described as strong and compelling. Factors influencing BPH development included serum testosterone and dihydrotestosterone levels, genetic predisposition to E. coli receptors, and frequency of sexual ejaculation after age 40. The manuscript also mentioned ongoing research into a vaccine for preventing BPH.