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Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

The skin has a complex immune system that is essential for protection and healing, requiring more research for better wound treatment.

The document concludes that the understanding of scar formation is incomplete and current prevention and treatment for hypertrophic scars and keloids are not fully effective.

The conclusion is that certain cell interactions and signals are crucial for hair growth and regeneration.

Certain proteins, Lgr5 and Lgr6, are important markers of adult stem cells and are involved in tissue repair and cancer development.

Alopecia areata is an autoimmune condition causing hair loss, influenced by genetics, stress, and diet, and may be prevented by a high soy oil diet.

Chemicals and body size might change when puberty starts and progresses, but more research is needed to confirm this.

Treatments that reduce oxidative stress and fix mitochondrial problems may help heal chronic wounds.

Epithelial-mesenchymal interactions control hair growth cycles through specific molecular signals.

The document concludes that mouse models are helpful but have limitations for skin wound healing research, and suggests using larger animals and genetically modified mice for better human application.

Chemotherapy can cause various skin reactions, with hair loss being the most common, and proper diagnosis and treatment of these reactions are important.

Some drugs can cause rare but potentially deadly skin reactions, and early treatment and avoiding the drug again are key.

The research shows that a gene called Wnt3 affects hair growth and structure, causing short hair and balding when overactive.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

Polymeric nanoparticles show promise for treating skin diseases.

PCOS is a complex disorder in women that can lead to various health risks and requires personalized treatment.

Teriflunomide helps reduce multiple sclerosis symptoms and is safe for most patients.

The immune system plays a key role in tissue repair, affecting both healing quality and regenerative ability.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.

Low iron and L-lysine levels can cause hair loss in women, and increasing these nutrients can reduce hair shedding.

Fat cells help recruit healing cells and build skin structure during wound healing.

Hidradenitis suppurativa, a chronic skin disease, can be managed with antibiotics, lifestyle changes, and in severe cases, surgery. Early diagnosis and careful planning are key, and laser treatment can be an efficient solution for mild to severe cases.

The report recommends personalized treatment for women's sexual dysfunctions and more research on effective therapies.

Msx and Dlx genes are crucial for development, controlling cell behaviors like growth and differentiation through their roles as gene regulators.

Middle-aged women with chronic telogen effluvium experience increased hair shedding but usually don't get significantly thinner hair.

PCOS is caused by both genetics and environmental factors like diet and obesity.