160 citations
,
July 2008 in “Experimental dermatology” This review discusses the protective effects and mechanisms of melatonin in skin and suggests potential therapeutic applications in cutaneous medicine, reporting no new clinical findings.
159 citations
,
October 1986 in “The Histochemical Journal” 159 citations
,
September 2018 in “Journal of Investigative Dermatology” This study identified two cell surface markers, FAP and CD90, that distinguish between papillary and reticular fibroblasts in human skin, suggesting distinct functions and distribution in dermal layers.
158 citations
,
January 2015 in “Artificial Intelligence in Medicine” This study found that DrugNet, a network-based prioritization method, effectively improves drug repositioning tasks, achieving high performance in validation tests and clinical trial comparisons.
158 citations
,
August 2011 in “Reviews in endocrine and metabolic disorders” This review examines the functions of vitamin D and its receptor in skin and explores how these are regulated, reporting no new clinical results.
158 citations
,
May 2003 in “Journal of Investigative Dermatology” This study observed that hair follicle mesenchyme in mice exhibits significant plasticity during the hair cycle, with cell migration and changes in papilla size impacting hair production.
158 citations
,
May 1968 in “The journal of nutrition/The Journal of nutrition” This study found that severe zinc deficiency induced in weanling rats led to growth retardation, hair issues, and dermal lesions, all of which were completely reversed by zinc supplementation.
158 citations
,
December 2002 in “Development” In this study, Msx2-deficient mice showed progressive hair loss due to shortened anagen phase and prolonged catagen and telogen phases, resulting in cyclic alopecia with structurally abnormal hair shafts.
157 citations
,
May 2021 in “Endocrine Reviews” This review discusses recent advancements in understanding and managing congenital adrenal hyperplasia, including improvements in screening, diagnostics, and potential genetic and cell-based treatments, but reports no new clinical findings.
157 citations
,
June 2011 Dermatoscopy and videodermatoscopy are useful for diagnosing and monitoring various skin, hair, and nail conditions.
157 citations
,
October 2003 in “Development” This study found that different stabilizing mutations in Aux/IAA proteins affect root hair development in Arabidopsis by disrupting the auxin response and suggest a model where the relative abundance of these proteins determines root hair initiation.
157 citations
,
June 2015 in “Psychoneuroendocrinology” This study observed that hair cortisol and cortisone concentrations were higher in older individuals and those with diabetes mellitus, highlighting their potential significance for assessing somatic health.
157 citations
,
September 2012 in “Journal of the American Academy of Dermatology” In this retrospective cohort study, researchers reported that 11.5% of patients with DRESS developed significant long-term autoimmune or renal sequelae, with age influencing the type of sequelae observed.
157 citations
,
April 1997 in “International journal of legal medicine” This study found that cosmetic hair treatments like bleaching and dyeing significantly reduced drug concentrations in hair samples, with decreases ranging from 30% to over 60% depending on the treatment and hair damage level.
156 citations
,
August 2016 in “Journal of controlled release” This review summarizes current knowledge on tight junctions in mammalian skin and their role in drug delivery and interaction with other barrier components, but reports no new experimental results.
156 citations
,
September 2014 in “British journal of dermatology/British journal of dermatology, Supplement” This guideline review discusses updated evidence-based recommendations for managing tinea capitis, with a focus on accurate diagnosis, effective treatment, and prevention strategies, but reports no new clinical results.
156 citations
,
January 1989 in “Genes & Development” This study found that keratin K14 expression occurs early in epidermal cell differentiation, while a hair-specific keratin is expressed later in hair matrix cells, suggesting developmental divergence between the two cell types.
155 citations
,
August 2003 in “Journal Of Experimental Zoology Part B: Molecular And Developmental Evolution” This review discusses the conserved molecular mechanisms controlling hair follicle development and cycling and suggests they may also apply to other ectodermal derivatives, like teeth and feathers, but it reports no new results.
153 citations
,
April 1998 in “Current Biology” This study found that benign tumors with a high risk of malignant progression primarily arise from hair follicle cells when a mutant ras gene is expressed in a specific population of epidermal cells in mice.
152 citations
,
December 2003 in “Micron” This review discusses the development, regulation, and aging of the human hair follicle pigmentary system and suggests potential for reversing hair graying by manipulating follicle melanocytes in vitro, but reports no clinical results.
152 citations
,
April 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” This study presents evidence that keratitis–ichthyosis–deafness syndrome is caused by a mutation in the connexin 26 gene, expanding the gene's known involvement in various disorders.
151 citations
,
November 2018 in “International Journal of Pharmaceutics” This review discusses various nanoparticles and nanoemulsions being investigated for transdermal drug delivery and reports no clinical results; it highlights potential applications in treating alopecia, wound healing, psoriasis, and melanoma.
151 citations
,
July 2011 in “Archives of Dermatological Research” This review discusses various strategies to enhance drug delivery through the skin barrier, highlighting liposomes as promising carriers for increased dermal concentrations in topical therapies, but reports no new research results.
151 citations
,
August 2010 in “British Journal of Dermatology” This guideline reviews the diagnosis of androgenetic alopecia and offers expert consensus recommendations tailored to males, females, and adolescents, but reports no new clinical results.
151 citations
,
June 2010 in “Endocrinology and metabolism clinics of North America” This article compares two rare genetic diseases, vitamin D-dependent rickets type 1 and type 2, focusing on their similar presentations of hypocalcemia and rickets in infancy, but reports no new clinical results.
151 citations
,
November 2014 in “Annual Review of Animal Biosciences” This review discusses three decades of progress in feather development, regeneration, and evolution, with no new experimental results; it highlights feathers' potential as a model for morphogenesis studies.
151 citations
,
February 2006 in “Stem Cells and Development” This study found that hair follicle-derived dermal stem cells and bone marrow mesenchymal stem cells have similar growth, differentiation capabilities, and surface marker expressions, suggesting hair follicles could be accessible sources for mesenchymal stem cells.
150 citations
,
October 2012 in “Clinical Endocrinology” In this retrospective cohort study, women with polycystic ovary syndrome showed high incidence and age-specific prevalence rates of type 2 diabetes, myocardial infarction, and angina, particularly in those over 65.
150 citations
,
May 1993 in “The journal of cell biology/The Journal of cell biology” This study suggests that mNotch expression plays a significant role in hair follicle differentiation and cell fate selection within the follicle during development.
150 citations
,
August 1992 in “Genes & Development” This study reported that transgenic mice with targeted TNF alpha expression in keratinocytes showed impaired weight gain, retarded hair growth, and skin changes, leading to cachexia and necrosis.