Long-Term Sequelae of Drug Reaction with Eosinophilia and Systemic Symptoms: A Retrospective Cohort Study from Taiwan

    September 2012 in “ Journal of the American Academy of Dermatology ”
    Yi‐Chun Chen, Chia-Ying Chang, Yung‐Tsu Cho, Hsien‐Ching Chiu, Chia‐Yu Chu
    TLDR Young patients are more likely to develop autoimmune diseases, while elderly patients are more prone to organ failure after DRESS.
    The study investigated the long-term sequelae and prognosis of patients with DRESS/drug-induced hypersensitivity syndrome in a cohort from northern Taiwan. Out of 52 patients, 6 (11.5%) developed long-term sequelae, including autoimmune diseases such as Graves disease, type 1 diabetes mellitus, and autoimmune hemolytic anemia, as well as renal failure requiring lifetime hemodialysis. Alopecia areata was observed in 1 patient with Graves disease. The study concluded that young patients were more likely to develop autoimmune diseases, while elderly patients were more prone to end-organ failure. The study was limited by its small sample size and lack of viral studies.
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