2 citations
,
September 2020 in “Biomedical materials” This study found that recombinant human hair keratin proteins K31 and K81 show greater potential for inducing skin cell differentiation compared to natural keratin coatings.
1 citations
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December 2025 in “Frontiers in Endocrinology” This review examines the potential role of gut microbiota and its metabolites in polycystic ovary syndrome (PCOS) and highlights the growing interest in this area; it reports no new clinical findings.
June 2026 in “Nano Research” In this study, researchers developed a novel 3D bio-printed skin scaffold using exosomes from liver cells, which enhanced wound healing by promoting cell growth, angiogenesis, and reducing inflammation in large skin injuries, suggesting potential applications in treating chronic skin conditions.
June 2026 in “Frontiers in Immunology” This review synthesizes both traditional and emerging molecular mechanisms of tissue remodeling across different organs, aiming to establish a theoretical basis for precision interventions in pathological conditions, according to the authors.
May 2026 in “Scientific Reports” In this study, researchers overexpressed Lrig3 in mouse skin and observed hair loss linked to changes in skin protein profiles and signaling pathways, suggesting a potential role for Lrig3 in maintaining skin homeostasis.
January 2025 in “Institutional Repositories DataBase (IRDB)” This study observed that topical application of maslinic acid stimulated hair growth in mice comparably to minoxidil, possibly through the Wnt/β-catenin pathway and involving ciliary gene activity, highlighting increased levels of trichogenic gene expression and protein levels.
April 2024 in “Journal of cancer research and clinical oncology” This review discusses the isolation, characterization, and potential clinical applications of tissue-derived extracellular vesicles in cancer diagnosis, prognosis, and treatment, noting their significance but highlighting the risks and need for appropriate protocols.
November 2022 in “Research Square (Research Square)” This study found that keratin-associated proteins related to metallothionein and occludin appear in various animals, suggesting they may have roles beyond hair characteristics and were later adapted for hair production.
January 2008 in “Durham e-Theses (Durham University)” This study observed that stem cells from the hair follicle dermis share similarities with bone marrow-derived mesenchymal stem cells and have potential to form neural-like cells under specific conditions.
1160 citations
,
November 2018 in “Physiological Reviews” This review discusses the potential of single cell technologies to improve understanding and treatment of impaired wound healing and reports no new clinical results.
658 citations
,
June 2003 in “Endocrine reviews” This review discusses the role of androgens in the progression of cardiovascular disease and explores novel therapeutic targets without reporting new clinical results.
306 citations
,
April 2019 in “International Journal of Molecular Sciences” This review discusses the protective roles of skin-resident immune cells in maintaining tissue homeostasis and facilitating wound healing, but reports no new experimental findings.
185 citations
,
June 2011 in “Molecular and cellular endocrinology” This review discusses the regulation and function of vitamin D and its receptor in skin cells, highlighting their roles in processes such as proliferation inhibition, differentiation, and innate immunity, but reports no new results.
174 citations
,
November 2016 in “Cell stem cell” This study found that squamous cell carcinomas from hair follicle stem cells are more prone to epithelial to mesenchymal transition and metastasis than those from interfollicular epidermis, due to distinct chromatin landscapes.
162 citations
,
August 2002 in “Survey of Ophthalmology” This study found that latanoprost induces significant growth and pigmentation of lashes and ancillary hairs, with effects mirroring both brief and chronic treatments observed in patients and animal models.
158 citations
,
August 2011 in “Reviews in endocrine and metabolic disorders” This review examines the functions of vitamin D and its receptor in skin and explores how these are regulated, reporting no new clinical results.
119 citations
,
July 2016 in “Annals of the New York Academy of Sciences” This review examines the impact of vitamin D signaling in extraskeletal tissues and notes that expected benefits from animal and cell studies have not been consistently replicated in human clinical trials.
89 citations
,
September 2010 in “Annual Review of Genomics and Human Genetics” This review discusses the genetic factors involved in hair follicle morphogenesis and cycling and reports no new clinical results; it emphasizes the role of genes in hereditary hair diseases.
86 citations
,
October 2005 in “Experimental Dermatology” This review explores the role of Foxn1 in mammalian skin biology, discussing its influence on hair follicle function and the potential for further research to enhance understanding of epithelial differentiation.
80 citations
,
April 2011 in “Plant physiology” This study suggests that the GPX-PDE1 and GPX-PDE2 genes in white lupin enhance root hair development and contribute to Pi limitation acclimation by facilitating glycerophosphodiester degradation.
77 citations
,
July 2013 in “Best Practice & Research in Clinical Obstetrics & Gynaecology” This review discusses the impact of menopause-related oestrogen deficiency on skin ageing and suggests that oestrogen use may improve collagen and skin elasticity, but it reports no clinical trial results.
61 citations
,
January 2008 in “Cold Spring Harbor Symposia on Quantitative Biology” This review examines beta-catenin's role in stem cell renewal, lineage selection, and tumor formation in the epidermis and reports no new experimental findings.
60 citations
,
August 2008 in “Human molecular genetics online/Human molecular genetics” This study suggests that a position effect disrupting TRPS1 expression may be linked to hypertrichosis in both Ambras syndrome in humans and a similar phenotype in Koa mice.
58 citations
,
March 2013 in “Human Reproduction Update” This review discusses various substances that can impact male fertility and stresses that products should be confirmed 'sperm-safe' through rigorous testing, not assumptions; it reports no new study results.
57 citations
,
March 2018 in “International Journal of Molecular Sciences” This review highlights recent advances in understanding how the extracellular matrix regulates epidermal stem cell fate, emphasizing the importance of the hair follicle stem cell niche, but reports no new empirical findings.
50 citations
,
April 2014 in “Nature Communications” This study analyzed skin from 538 knockout mouse mutants and identified 50 with epidermal phenotypes, providing valuable insights into genetic conditions and systemic effects related to skin abnormalities.
49 citations
,
August 2016 in “Aesthetic Surgery Journal” This study found that micro-needling with cosmeceuticals or platelet-rich plasma significantly improved wrinkles, skin laxity, scar softening, and hair growth over 12 months, with minimal side effects, and that the best results occur with pigment and platelet massaging between 5 to 30 minutes post-treatment.
47 citations
,
December 2019 in “Biomaterials” This study demonstrated effective delivery of CRISPR/Cas9 components to dermal papilla cells in androgenic alopecia animals using ultrasound-activated nanoparticles, resulting in specific gene editing and hair growth recovery.
47 citations
,
July 2013 in “Pharmacological Reviews” This review discusses the role of pharmacological sciences in advancing regenerative medicine technologies but reports no new experimental findings; the authors advocate for increased pharmacologist involvement to drive innovations.
42 citations
,
March 2008 in “Molecular and Cellular Endocrinology” This review explores the potential (neuro-)endocrine influences on hair follicle epithelial stem cell biology and emphasizes the need for more systematic research, but it provides no new empirical results.