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The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

Melatonin may help with sleep issues, depression, and cancer, but more research is needed.

The Rotterdam Study aims to understand various diseases in older adults.

Chemotherapy causes hair loss by damaging hair follicles and stem cells, with more research needed for prevention and treatment.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Testing basal 17-HP levels is a good way to screen for nonclassic adrenal hyperplasia in women with high androgen levels.

Diagnosing PCOS in teenagers is challenging and should use strict criteria to avoid misdiagnosis and unnecessary worry.

Finasteride effectively treats BPH, but needs more trials to understand potential.

Pregnancy can cause various skin changes and diseases, with PUPPP being the most common skin condition specific to pregnancy.

Hormone therapy for trans individuals is effective and generally safe in the short term.

Most women with excess hair growth have an underlying hormonal issue, often treated with medication and hair removal methods.

Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.

Opioid painkillers can cause many side effects, including breathing problems and addiction, but are generally considered safe when used properly.

Hair follicles significantly increase the speed and amount of caffeine absorbed through the skin.

Androgens can help prevent memory problems caused by apoE4.

Lower doses of treatments for hirsutism and acne in PCOS are effective and cause fewer side effects.

Scientists found a new, less invasive way to study body clocks using hair cells, which shows shift workers' body clocks don't match their lifestyles.

Flutamide is more effective and has fewer side effects than spironolactone for treating hirsutism.

Testosterone therapy in transgender men has both desired effects like increased muscle mass and potential health risks such as higher cardiovascular risk.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Androgens can cause hair growth in some areas and hair loss on the scalp.

Guidelines for diagnosing common hair loss include detailed history, clinical examination, and various diagnostic techniques.

Women with PCOS have overall higher body fat, not abnormal fat placement, and more insulin resistance.

Some drugs can cause hair loss or increase hair growth, but these effects are usually reversible when the drug is stopped.

Different types of polycystic ovary syndrome (PCOS) have varying severity, with Type I being the most severe and common.

Hair follicles may soon be used more for targeted and systemic drug delivery.

Pregnancy can cause skin darkening, varicose veins, more sweating, hair growth, hair loss after birth, nail changes, and gum inflammation.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.